DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and KCNA4

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_002224.1	Gene:	KCNA4 / 3739	HGNCID:	6222	Length:	653	Species:	Homo sapiens

Alignment Length:	397	Identity:	95/397 - (23%)
Similarity:	158/397 - (39%)	Gaps:	103/397 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|....:
Human   213 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALL 267

  Fly    53 RYR-----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFS 94
            ::|                 ..:.:::...|.|      ||:..:...|::..:|..||     .
Human   268 KFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCL-----E 327

  Fly    95 TIKEYEEDAVYIL-------------------------------FRMEILVVIWFTMEFGARLWS 128
            |:.|:.:|...::                               |.:|.:.::||:.||..|.::
Human   328 TLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA 392

  Fly   129 SGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM----------GTSGQVFATSALRGLRF 183
                     |..:..|.|....|||||:||...:.||.          |...|..:.:.||.:|.
Human   393 ---------CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRL 448

  Fly   184 FQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKD-VNDKFSNFAQ 247
            .::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..|.| ....|.:...
Human   449 VRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPD 513

  Fly   248 ALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIR 312
            |.||.|:|:.|||||||.|||..||::.|.||:.|:...|||..::.|.|.....::...:...:
Human   514 AFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQ 578

  Fly   313 RRQPAAT 319
            ..|.|.:
Human   579 LTQNAVS 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/246 (27%)
		Ion_trans_2	221..295	CDD:285168	33/74 (45%)
		KCNQ_channel	<619..719	CDD:281513
KCNA4	NP_002224.1	K_channel_TID	1..>37	CDD:400339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..148
		BTB_POZ	176..303	CDD:365784	18/99 (18%)
		Ion_trans	306..570	CDD:395416	75/277 (27%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	462..475		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	524..529		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..653
		PDZ-binding. /evidence=ECO:0000250	651..653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810