DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNA3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_002223.3	Gene:	KCNA3 / 3738	HGNCID:	6221	Length:	575	Species:	Homo sapiens

Alignment Length:	430	Identity:	103/430 - (23%)
Similarity:	172/430 - (40%)	Gaps:	104/430 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PDNDIYAFYDIRGYKGKCRPGRP-------NSERILQPRMSLLGKPL--------NYNRGTRRDV 52
            |..|...:|    |:...|..||       .||.|   |...||:..        .:.|...|.:
Human   154 PSFDAILYY----YQSGGRIRRPVNVPIDIFSEEI---RFYQLGEEAMEKFREDEGFLREEERPL 211

  Fly    53 RYRRLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY------ 105
            ..|..|.:::...|.|      ||:..:...|::..:|..||     .|:.|:.::..|
Human   212 PRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCL-----ETLPEFRDEKDYPASTSQ 271

  Fly   106 ----------------------ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRP 148
                                  ..|.:|.|.:|||:.|...|.::         |..:..|.:..
Human   272 DSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFA---------CPSKATFSRNI 327

  Fly   149 FCIIDIVTILASIVVLG------MGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVY 207
            ..:||||.|:...:.||      .|...|..:.:.||.:|..::.|:.::.|.....::||..:.
Human   328 MNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK 392

  Fly   208 AHRQELITTMYIGFLGLIFASFLVYMWE-KDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQG 271
            |..:||...::..|:|:|..|..||..| .|....||:...|.||.|:|:.|||||||.|:|..|
Human   393 ASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGG 457

  Fly   272 KLIASCCALLGISFFALPAGILGSGF------ALKVQQQQRQKHM------------IRRRQPAA 318
            |::.|.||:.|:...|||..::.|.|      ..:.::|.:..|:            :|:.:..:
Human   458 KIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNS 522

  Fly   319 TLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSS 358
            ||        :..|:.| :....::..|.|..|....:|:
Human   523 TL--------SKSEYMV-IEEGGMNHSAFPQTPFKTGNST 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	65/245 (27%)
		Ion_trans_2	221..295	CDD:285168	33/74 (45%)
		KCNQ_channel	<619..719	CDD:281513
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		BTB	106..200	CDD:197585	13/52 (25%)
		BTB_2	106..197	CDD:280393	13/49 (27%)
		Ion_trans	290..490	CDD:278921	64/208 (31%)
		Ion_trans_2	404..481	CDD:285168	33/76 (43%)
		Selectivity filter. /evidence=ECO:0000250	444..449		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	573..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810