Protein Alignment KCNQ and KCNA2

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 123/526 - (23%)
• Similarity: 194/526 - (36%)
• Gaps: 178/526 - (33%)

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGT---- 48
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.
Human    70 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAME 124

  Fly    49 --RRDVRYRRLQSR-------------LYNFLER--PRGLHAIFYHVMVFL--MVFTCL-ALSVF 93
              |.|..|.:.:.|             |:.:.|.  |..:.|| ..|||.|  :|..|| .|.:|
Human   125 MFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAI-VSVMVILISIVSFCLETLPIF 188

  Fly    94 -------------------STIKEYEEDAVYI--LFRMEILVVIWFTMEFGARLWSSGCRSRYQG 137
                               ||| .|::...:.  .|.:|.|.:|||:.||..|.::
Human   189 RDENEDMHGSGVTFHTYSNSTI-GYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFA--------- 243

  Fly   138 CLGRLKFVKRPFCIIDIVTILASIVVLGMGTS---------GQVFATSALRGLRFFQILRMVRMD 193
            |..:..|......|||||.|:...:.||...:         .|..:.:.||.:|..::.|:.::.
Human   244 CPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLS 308

  Fly   194 RRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVND-KFSNFAQALWWGVITLC 257
            |.....::||..:.|..:||...::..|:|:|..|..||..|.|..: :|.:...|.||.|:::.
Human   309 RHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMT 373

  Fly   258 TVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQ 322
            |||||||||.|..||::.|.||:.|:...|||..::.|.|.....::...:...:..|
Human   374 TVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ------- 431

  Fly   323 AVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGD 387
             |..|                    |..|:|                |.:::.:|
Human   432 -VTSC--------------------PKIPSS----------------PDLKKSRS---------- 449

  Fly   388 GGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQ 452
                        |||        |:.| :.:|:.:...:.|..|.|:::....|
Human   450 ------------AST--------ISKS-DYMEIQEGVNNSNEDFREENLKTANC----------- 482

  Fly   453 PATLAN 458
              ||||
Human   483 --TLAN 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/216 (30%)
		Ion_trans_2	221..295	CDD:285168	32/74 (43%)
		KCNQ_channel	<619..719	CDD:281513
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125		15/64 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784	21/98 (21%)
		Ion_trans	162..420	CDD:395416	79/268 (29%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810