DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNA1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_000208.2	Gene:	KCNA1 / 3736	HGNCID:	6218	Length:	495	Species:	Homo sapiens

Alignment Length:	362	Identity:	92/362 - (25%)
Similarity:	147/362 - (40%)	Gaps:	90/362 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
Human    74 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME 128

  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95
            ::|                ..|.:::...|.|      |.:..:...|::..:|..||     .|
Human   129 KFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL-----ET 188

  Fly    96 IKEYEEDAVYI---------------------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCL 139
            :.|.::|..:.                     .|.:|.|.:|||:.|...|.::         |.
Human   189 LPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFA---------CP 244

  Fly   140 GRLKFVKRPFCIIDIVTILASIVVLGM------GTSGQVFATS--ALRGLRFFQILRMVRMDRRG 196
            .:..|.|.....||||.|:...:.||.      |......|||  .||.:|..::.|:.::.|..
Human   245 SKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHS 309

  Fly   197 GTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE-KDVNDKFSNFAQALWWGVITLCTVG 260
            ...::||..:.|..:||...::..|:|:|..|..||..| ::....||:...|.||.|:::.|||
Human   310 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVG 374

  Fly   261 YGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297
            ||||.|:|..||::.|.||:.|:...|||..::.|.|
Human   375 YGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	66/228 (29%)
		Ion_trans_2	221..295	CDD:285168	31/74 (42%)
		KCNQ_channel	<619..719	CDD:281513
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P10499	1..128		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_2	39..130	CDD:308049	15/65 (23%)
		Ion_trans	166..418	CDD:306908	73/260 (28%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810