DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcna7

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001102384.1	Gene:	Kcna7 / 365241	RGDID:	1309632	Length:	489	Species:	Rattus norvegicus

Alignment Length:	224	Identity:	66/224 - (29%)
Similarity:	108/224 - (48%)	Gaps:	20/224 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLG------M 166
            |.:|.|.:.||:.|...||         ..|..:..|.|....:||.|.||...|.||      .
  Rat   243 FVVETLCICWFSFELLVRL---------AACPSKAVFFKNVMNLIDFVAILPYFVALGTELARQR 298

  Fly   167 GTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLV 231
            |......:.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..|:|::..|..|
  Rat   299 GVGQPAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAV 363

  Fly   232 YMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGS 295
            |..|.|..| .|::..::.||.|:|:.|||||||.|:|..||::.|.||:.|:...:||..::.|
  Rat   364 YFAEVDRADTHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVS 428

  Fly   296 GFAL----KVQQQQRQKHMIRRRQPAATL 320
            .|:.    :.:.::...:.....||..||
  Rat   429 NFSYFYHRETEGEEAGMYSHVDTQPCGTL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/207 (30%)
		Ion_trans_2	221..295	CDD:285168	30/74 (41%)
		KCNQ_channel	<619..719	CDD:281513
Kcna7	NP_001102384.1	BTB_2	47..137	CDD:280393
		BTB	47..130	CDD:197585
		Ion_trans	228..437	CDD:278921	62/202 (31%)
		Ion_trans_2	352..431	CDD:285168	31/78 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900