Protein Alignment KCNQ and kcnd3

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_005167059.1
• Gene: kcnd3 / 327415
• ZFINID: ZDB-GENE-030131-5626
• Length: 650
• Species: Danio rerio
• Alignment Length: 615
• Identity: 138/615 - (22%)
• Similarity: 230/615 - (37%)
• Gaps: 190/615 - (30%)

  Fly    24 RPNSERILQPRMSLLGKPLNYNRGTR-RDVRYRRLQSRLYNFLERPR--GLHAIFYHVMVFLMVF 85
            |.|:||::.        .|..|:.:: .::.:|....|.:   |.|.  .:..:||:|..|.
Zfish   141 RENTERLMD--------DLEDNKDSKLPNMTFRETMWRAF---ENPHTSTMALVFYYVTGFF--- 191

  Fly    86 TCLALSVFSTIKE------------------YEEDAVYILFRMEILVVIWFTMEFGARLWSSGCR 132
              :||||.:.:.|                  |.|    ..|.|:...|:.||:|:..||:::  .
Zfish   192 --IALSVITNVVETVPCGYMPNQRDVPCGERYTE----AFFCMDTACVMIFTVEYLMRLFAA--P 248

  Fly   133 SRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGG 197
            |||       :|::....|||:|.||...:.|.|..:..|  :.|...||.|::.|:.:..|...
Zfish   249 SRY-------RFMRSVMSIIDVVAILPYYIGLVMTNNEDV--SGAFVTLRVFRVFRIFKFSRHSQ 304

  Fly   198 TWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFLVYMWEKDVNDKFSNFAQALWWGVIT 255
            ..::||..:.:...||      |||       .:|||:.:.|..:...:.||::...:.|:.::|
Zfish   305 GLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVMFYAEKGSSSSKFTSIPASFWYTIVT 363

  Fly   256 LCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQR-QKHMIRRRQPAAT 319
            :.|:|||||||.|..||:..|.|:|.|:...|||..::.|.|:....|.|| .|...::.|.|
Zfish   364 MTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKVQKA-- 426

  Fly   320 LIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKH------NTSF-VARLPTIRRHKS 377
                                    |:|......|.:|::|.|      |.|. :.:||..:...|
Zfish   427 ------------------------RLARMRISKSGSSTAFLHSKRNGLNQSLELTQLPYYKMKLS 467

  Fly   378 QTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENL------------------------ 418
                            |.||.....:..:|...:.:...:|
Zfish   468 ----------------PQGSLEEDQQLKKTTSLLESQHHHLLHCLEKTTNHEFVDERLYEQGYLQ 516

  Fly   419 EVVQNGKSMNPSF-SEDSVAETTC----LKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDR 478
            ..:||..|.:||. ||:.:..|.|    .|||:..:|:...:..:.....||..:
Zfish   517 TALQNFPSQSPSLSSEEGITGTCCSRRPKKNIQPLNATHTHSHTHNLQELSALHI---------- 571

  Fly   479 DQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLH----GNFLGSTLSLRNPRVAPANDRD 539
                         |..||.....||.:|.:.....|.|:    |....:.:|:..|   |:|:
Zfish   572 -------------QCGEQQPLNTSRSSLNLMSDESGSLNCKSSGLVTTAIISIPTP---PSNN-- 618

  Fly   540 LEAGRDEDEVHKDTCQRSNTLPLPVKPDSP 569
                          .:.|...|.|..|::|
Zfish   619 --------------SRASPDAPSPPNPEAP 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/211 (30%)
		Ion_trans_2	221..295	CDD:285168	28/80 (35%)
		KCNQ_channel	<619..719	CDD:281513
kcnd3	XP_005167059.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585
		BTB_2	42..131	CDD:280393
		Ion_trans	213..411	CDD:278921	64/218 (29%)
		Ion_trans_2	327..407	CDD:285168	28/79 (35%)
		DUF3399	443..556	CDD:288712	24/128 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910