Protein Alignment KCNQ and Kcng2

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001100842.1
• Gene: Kcng2 / 307234
• RGDID: 1309521
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 278
• Identity: 84/278 - (30%)
• Similarity: 130/278 - (46%)
• Gaps: 36/278 - (12%)

  Fly    53 RYRRLQSRLYNFLERPR-GLHA-IFYHVMVFLMVFTC--LALSVFSTIKEYEE-----DAVYILF 108
            |..|.:.||.:.:|.|. ||.. :|.:|.|..:..|.  |.||....::..||     .....||
  Rat   168 RLERGRRRLRDVVENPHSGLAGKLFAYVSVAFVAVTAVGLCLSTMPDVRAEEERGECSTKCRNLF 232

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL----ASIVVLGMGTS 169
            .:|.:.|.||:.||..|...:.         .:..|::.|..||||:.||    :.:..|..|.:
  Rat   233 VLETVCVAWFSFEFLLRSLQAE---------SKCAFLRTPLAIIDILAILPFYVSLLAGLAAGPT 288

  Fly   170 GQVFATSA---LRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASF-- 229
            |......|   ||.||..::|.::|:.|.....:.||..|....:|.  .:.:.||.:..|.|
  Rat   289 GSKMLERAGLVLRLLRALRVLYVMRLARHSLGLRSLGLTVRRCAREF--GLLLLFLCVAMALFAP 351

  Fly   230 LVYMWEKDV--NDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGI 292
            ||::.|:::  :..||:...:.||.||::.|||||||||.:..|:::|....|.||...|.|...
  Rat   352 LVHLAERELGAHRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTS 416

  Fly   293 LGSGFA-----LKVQQQQ 305
            :...|:     ||.|||:
  Rat   417 IFHTFSRSYSELKEQQQR 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	75/256 (29%)
		KCNQ_channel	<619..719	CDD:460954
Kcng2	NP_001100842.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		BTB_POZ_Kv6_KCNG	33..127	CDD:349691
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	144..167
		Ion_trans	190..429	CDD:459842	71/249 (29%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	382..387		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..480		4/6 (67%)