Protein Alignment KCNQ and Kcna3

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_062143.3
• Gene: Kcna3 / 29731
• RGDID: 2951
• Length: 525
• Species: Rattus norvegicus
• Alignment Length: 430
• Identity: 102/430 - (23%)
• Similarity: 173/430 - (40%)
• Gaps: 104/430 - (24%)

  Fly     3 PDNDIYAFYDIRGYKGKCRPGRP-------NSERILQPRMSLLGKPL--------NYNRGTRRDV 52
            |..|...:|    |:...|..||       .||.|   |...||:..        .:.|...|.:
  Rat   104 PSFDAILYY----YQSGGRIRRPVNVPIDIFSEEI---RFYQLGEEAMEKFREDEGFLREEERPL 161

  Fly    53 RYRRLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY------ 105
            ..|..|.:::...|.|      ||:..:...|::..:|..||     .|:.|:.::..|
  Rat   162 PRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCL-----ETLPEFRDEKDYPASPSQ 221

  Fly   106 ----------------------ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRP 148
                                  ..|.:|.|.:|||:.|...|.::         |..:..|.:..
  Rat   222 DVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFA---------CPSKATFSRNI 277

  Fly   149 FCIIDIVTILASIVVLG------MGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVY 207
            ..:||||.|:...:.||      .|...|..:.:.||.:|..::.|:.::.|.....::||..:.
  Rat   278 MNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLK 342

  Fly   208 AHRQELITTMYIGFLGLIFASFLVYMWE-KDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQG 271
            |..:||...::..|:|:|..|..||..| .|.:..|::...|.||.|:|:.|||||||.|:|..|
  Rat   343 ASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGG 407

  Fly   272 KLIASCCALLGISFFALPAGILGSGF------ALKVQQQQRQKHM------------IRRRQPAA 318
            |::.|.||:.|:...|||..::.|.|      ..:.::|.:..|:            :|:.:..:
  Rat   408 KIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNS 472

  Fly   319 TLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSS 358
            ||        :..|:.| :....::..|.|..|....:|:
  Rat   473 TL--------SKSEYMV-IEEGGMNHSAFPQTPFKTGNST 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	70/273 (26%)
		KCNQ_channel	<619..719	CDD:460954
Kcna3	NP_062143.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		BTB_POZ	54..180	CDD:453885	19/82 (23%)
		Ion_trans	183..440	CDD:459842	72/270 (27%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	394..399		4/4 (100%)
		Interaction with KCNE4. /evidence=ECO:0000269|PubMed:27802162	432..525		12/81 (15%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:7477295	523..525