Protein Alignment KCNQ and Kcnq5

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001128115.2
• Gene: Kcnq5 / 259273
• RGDID: 628848
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 1060
• Identity: 365/1060 - (34%)
• Similarity: 484/1060 - (45%)
• Gaps: 310/1060 - (29%)

  Fly    34 RMSLLGKPLNY--NRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTI 96
            |||||||||:|  ::..||:|:|||:|:.|||.|||||| .|..||..|||:||.||.|||||||
  Rat    85 RMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRG-WAFVYHAFVFLLVFGCLILSVFSTI 148

  Fly    97 KEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASI 161
            .|:.:.|...|..:|.::::.|.:||..|:||:||..||:|..|||:|.::|||:||.:.::|||
  Rat   149 PEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASI 213

  Fly   162 VVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
            .|:...|.|.:|||||||.|||.|||||||||||||||||||||||||.:||||..|||||.|||
  Rat   214 AVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIF 278

  Fly   227 ASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAG 291
            :|||||:.|||.|.:||.:|.|||||.|||.|:||||..|:||.|:|:::..|||||||||||||
  Rat   279 SSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAG 343

  Fly   292 ILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALP--SP---- 350
            |||||||||||:|.||||..:||.|||.|||.|||.|||||.|||:|||..|..||.  ||
  Rat   344 ILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKE 408

  Fly   351 PASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASV 415
            ....|||.|..|.....|:.|.|: :||.:...   :...::.|.|.|         |:...|||
  Rat   409 QGEAASSKFCSNKQKFFRMYTSRK-QSQKLSFK---ERVRMASPRGQS---------IKSRQASV 460

  Fly   416 ENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQ 480
                    |...:|  |.|..||.:..|..|:                     ..|.||.|.|
  Rat   461 --------GDRRSP--STDITAEGSPTKVQKS---------------------WSFNDRTRFR-- 492

  Fly   481 DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
                                                      .:|.|::.:.....|.|...|.|
  Rat   493 ------------------------------------------PSLRLKSSQPKTVIDADTALGID 515

  Fly   546 EDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPR 610
             |...:..||                                            .||:.|:
  Rat   516 -DVYDEKGCQ--------------------------------------------CDVSVED---- 531

  Fly   611 CTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQIL 675
               ||...||.||.||.:|:.||:|||||.|:|||||||:|||:|||:|:|.|:|.|..|:||||
  Rat   532 ---LTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIL 593

  Fly   676 GK------QGSKAK-----DVYASKISLASRVVKVERQVADIEEKLDILIKAY------------ 717
            ||      :.|:.|     :.....:|:..||||||:||..||.|||.|:..|
  Rat   594 GKGQITSDKKSREKITAEHETTTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASAL 658

  Fly   718 ---------------------MEDRD-----------------------RFLALP--------LP 730
                                 :|.:|                       :|:..|        ..
  Rat   659 TLTSFQIPPFECEQTSDYQSPVESKDLSSSAQNSGCLSRSASANISRGLQFILTPNEFSAQTFYA 723

  Fly   731 AKPKIHSISPSHKPLHH--------AHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELR 787
            ..|.:|| ..:..|:..        .:|||               .|::..|  .|:||.:.::
  Rat   724 LSPTMHS-QTTQVPMSQNDGSSVVATNNLA---------------NQISAAP--KPAAPTTLQI- 769

  Fly   788 SLTATQTPTTTTDAIATQTPM---PPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTK 849
                 ..|.:....::...|:   ||.|..:.::..:.::.|        :.|..|..  .|.||
  Rat   770 -----PPPLSAIKHLSRPEPLLSNPPGVHESISDVTTCLVAS--------KENVQFAQ--SNLTK 819

  Fly   850 KRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCE--- 911
            .|   ||.:|.              |.|.::|.|.....|.|....|..:......|:||.:
  Rat   820 DR---SLRKSF--------------DMGGETLLSVRPMVPKDLGKSLSVQNLIRSTEELNLQFSG 867

  Fly   912 -------GEMDHFPTWE------IDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPI 963
                   |..|.:|.|.      .|.::|.| :.:.|..........:.|....:.||
  Rat   868 SESSGSRGSQDFYPKWRESKLFITDEEVGAE-ETETDTFDGTPPPAGEAAFSSDSLRT------- 924

  Fly   964 SPVSSAHNLQQLNDQTTTLN 983
            ....|:.|:.:..|.|..|:
  Rat   925 GRSRSSQNICKTGDSTDALS 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	130/204 (64%)
		Ion_trans_2	221..295	CDD:285168	50/73 (68%)
		KCNQ_channel	<619..719	CDD:281513	58/143 (41%)
Kcnq5	NP_001128115.2	Ion_trans	159..357	CDD:278921	129/197 (65%)
		Ion_trans_2	273..347	CDD:285168	50/73 (68%)
		KCNQ_channel	471..659	CDD:281513	81/304 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1342
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1440
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44832
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870