DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and Kcna5

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_037104.1	Gene:	Kcna5 / 25470	RGDID:	2953	Length:	602	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	99/411 - (24%)
Similarity:	158/411 - (38%)	Gaps:	129/411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
  Rat   148 DPLRNEY-FFD---------RNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAME 202

  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95
            |:|                ..|.:::...|.|      |.:..:...|::..::..||     .|
  Rat   203 RFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCL-----ET 262

  Fly    96 IKEYEEDAVYI-----------------------------------------LFRMEILVVIWFT 119
            :.|:.::...:                                         .|.:|...|||||
  Rat   263 LPEFRDERELLRHPPVPPQPPAPAPGINGSVSGALSSGPTVAPLLPRTLADPFFIVETTCVIWFT 327

  Fly   120 MEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM----------GTSG-QVF 173
            .|...|.::         |..:.:|.:....|||:|.|....:.||.          |.:| |..
  Rat   328 FELLVRFFA---------CPSKAEFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGQNGQQAM 383

  Fly   174 ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDV 238
            :.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..|.|.
  Rat   384 SLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADN 448

  Fly   239 N-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF----- 297
            : ..||:...|.||.|:|:.|||||||.|||..||::.|.||:.|:...|||..::.|.|
  Rat   449 HGSHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 513

  Fly   298 ---------ALKVQQ--QQRQ 307
                     |||.:|  |:|:
  Rat   514 RETDHEEQAALKEEQGNQRRE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	71/273 (26%)
		Ion_trans_2	221..295	CDD:285168	34/74 (46%)
		KCNQ_channel	<619..719	CDD:281513
Kcna5	NP_037104.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..107
		BTB	113..207	CDD:197585	17/68 (25%)
		BTB_2	113..204	CDD:280393	15/65 (23%)
		Ion_trans	305..515	CDD:278921	67/218 (31%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	407..420		3/12 (25%)
		Ion_trans_2	429..506	CDD:285168	34/76 (45%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	469..474		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..543		6/12 (50%)
		PDZ-binding	600..602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900