DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNQ and Kcnc2

DIOPT Version :10

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_631963.1 Gene:Kcnc2 / 246153 RGDID:628829 Length:638 Species:Rattus norvegicus


Alignment Length:466 Identity:119/466 - (25%)
Similarity:194/466 - (41%) Gaps:103/466 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DIYAFYDIRGYKGKCRPGRPNSERIL-QPRMSL-----LGKPLNYNRGTRRDVRYRRLQSRLYNF 64
            ||:...|:.|       |.|..:..| ..|:.:     ||.|      ..:..|:|:||.|::..
  Rat   167 DIFETPDLIG-------GDPGDDEDLGGKRLGIEDAAGLGGP------DGKSGRWRKLQPRMWAL 218

  Fly    65 LERP---RGLHAIFYHVMVFLMVFT---CL---------------ALSVFSTIKEYEEDAVYILF 108
            .|.|   |....|.:..:.|::|..   ||               .::..|.:.:||.:....|.
  Rat   219 FEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYEIETDPALT 283

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM-GTSGQV 172
            .:|.:.|:|||.||..|:..|.         .:|:|:|....|||.|.||...:.:|: |.|.:.
  Rat   284 YVEGVCVVWFTFEFLVRIVFSP---------NKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKA 339

  Fly   173 F--ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE 235
            .  ....||.:||.:|||:.::.|.....::||..:.|...|.:..:....||::..:.::|..|
  Rat   340 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAE 404

  Fly   236 K---DVND-------KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            :   ..||       :|.|.....||.|:|:.|:|||||.|.||.|.|:.:.|||.|:...|:|.
  Rat   405 RVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPV 469

  Fly   291 GILGSGFALKVQQQQRQKHMIRRRQ---PAATLIQAVWRCYA----------AD----------E 332
            .::.:.|.:.......::.:.|:|:   |.|.|..:...|..          :|          |
  Rat   470 PVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASSPTFCKTELNMACNSTQSDTCLGKENRLLE 534

  Fly   333 HSVSVATWNIHRVALP--SPPAS---RASSSFKHNTSFVARLPTIRRHKSQTIQTPGG---GDGG 389
            |:.||.:.:....:.|  |||..   |.||:...|          ||.::..:.|.|.   ...|
  Rat   535 HNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKN----------RRGETCFLLTTGDYTCASDG 589

  Fly   390 GVSKPPGSSRA 400
            |:.|....||:
  Rat   590 GIRKGYEKSRS 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 72/263 (27%)
KCNQ_channel <619..719 CDD:460954
Kcnc2NP_631963.1 BTB_KCNC2_4 7..166 CDD:349722
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 47..75
Ion_trans 228..484 CDD:459842 72/264 (27%)
Selectivity filter. /evidence=ECO:0000250 437..442 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..572 11/43 (26%)
Blue background indicates that the domain is not in the aligned region.

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