DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcnc2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_631963.1	Gene:	Kcnc2 / 246153	RGDID:	628829	Length:	638	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	122/471 - (25%)
Similarity:	197/471 - (41%)	Gaps:	113/471 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DIYAFYDIRGYKGKCRPGRPNSERIL-QPRMSL-----LGKPLNYNRGTRRDVRYRRLQSRLYNF 64
            ||:...|:.|       |.|..:..| ..|:.:     ||.|      ..:..|:|:||.|::..
  Rat   167 DIFETPDLIG-------GDPGDDEDLGGKRLGIEDAAGLGGP------DGKSGRWRKLQPRMWAL 218

  Fly    65 LERP---RGLHAIFYHVMVFLMVFT---CL---------------ALSVFSTIKEYEEDAVYILF 108
            .|.|   |....|.:..:.|::|..   ||               .::..|.:.:||.:....|.
  Rat   219 FEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYEIETDPALT 283

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM-GTSGQV 172
            .:|.:.|:|||.||..|:..|.         .:|:|:|....|||.|.||...:.:|: |.|.:.
  Rat   284 YVEGVCVVWFTFEFLVRIVFSP---------NKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKA 339

  Fly   173 F--ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE 235
            .  ....||.:||.:|||:.::.|.....::||..:.|...|.:..:....||::..:.::|..|
  Rat   340 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAE 404

  Fly   236 K---DVND-------KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            :   ..||       :|.|.....||.|:|:.|:|||||.|.||.|.|:.:.|||.|:...|:|.
  Rat   405 RVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPV 469

  Fly   291 GIL----GSGFALKVQQQ----QRQKHMIRRRQPAATLIQAVWRCYA----------AD------ 331
            .::    |..::|.:.:|    :|:||:     |.|.|..:...|..          :|
  Rat   470 PVIVNNFGMYYSLAMAKQKLPRKRKKHI-----PPAPLASSPTFCKTELNMACNSTQSDTCLGKE 529

  Fly   332 ----EHSVSVATWNIHRVALP--SPPAS---RASSSFKHNTSFVARLPTIRRHKSQTIQTPGG-- 385
                ||:.||.:.:....:.|  |||..   |.||:...|          ||.::..:.|.|.
  Rat   530 NRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKN----------RRGETCFLLTTGDYT 584

  Fly   386 -GDGGGVSKPPGSSRA 400
             ...||:.|....||:
  Rat   585 CASDGGIRKGYEKSRS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/225 (30%)
		Ion_trans_2	221..295	CDD:285168	29/87 (33%)
		KCNQ_channel	<619..719	CDD:281513
Kcnc2	NP_631963.1	BTB	10..159	CDD:197585
		BTB_2	10..151	CDD:280393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..75
		Ion_trans	277..484	CDD:278921	65/215 (30%)
		Ion_trans_2	<427..474	CDD:285168	21/46 (46%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..572		11/43 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810