DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcna1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_775118.1	Gene:	Kcna1 / 24520	RGDID:	2949	Length:	495	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	93/362 - (25%)
Similarity:	148/362 - (40%)	Gaps:	90/362 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
  Rat    74 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME 128

  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95
            ::|                ..|.:::...|.|      |.:..:...|::..:|..||     .|
  Rat   129 KFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL-----ET 188

  Fly    96 IKEYEED--------------AVYI-------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCL 139
            :.|.::|              .:|.       .|.:|.|.:|||:.|...|.::         |.
  Rat   189 LPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFA---------CP 244

  Fly   140 GRLKFVKRPFCIIDIVTILASIVVLGM------GTSGQVFATS--ALRGLRFFQILRMVRMDRRG 196
            .:..|.|.....||||.|:...:.||.      |......|||  .||.:|..::.|:.::.|..
  Rat   245 SKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHS 309

  Fly   197 GTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE-KDVNDKFSNFAQALWWGVITLCTVG 260
            ...::||..:.|..:||...::..|:|:|..|..||..| ::....||:...|.||.|:::.|||
  Rat   310 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVG 374

  Fly   261 YGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297
            ||||.|:|..||::.|.||:.|:...|||..::.|.|
  Rat   375 YGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/228 (29%)
		Ion_trans_2	221..295	CDD:285168	31/74 (42%)
		KCNQ_channel	<619..719	CDD:281513
Kcna1	NP_775118.1	Tetramerization domain. /evidence=ECO:0000305	1..128		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:365784	19/98 (19%)
		Ion_trans	166..418	CDD:395416	74/260 (28%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000305	493..495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810