DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcna10

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001074609.1	Gene:	Kcna10 / 242151	MGIID:	3037820	Length:	511	Species:	Mus musculus

Alignment Length:	259	Identity:	70/259 - (27%)
Similarity:	115/259 - (44%)	Gaps:	44/259 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYIL----------------------FRME 111
            ||:..:...|:|..:...||     .|:.|:.||....:                      |.:|
Mouse   216 RGVAVVSVLVVVISITIFCL-----ETLPEFREDRELKVVRDPSINTNKTGLSQTMFTDPFFMVE 275

  Fly   112 ILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIV-------TILASIVVLGMGTS 169
            ...::|||.|...         |:..|..:..|.|....||||:       |::..:|.....::
Mouse   276 STCIVWFTFELVL---------RFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSA 331

  Fly   170 GQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMW 234
            .|..:.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..
Mouse   332 QQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFA 396

  Fly   235 EKDVNDK-FSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297
            |.|..:. ||:.....||.|:|:.|||||||.|.|..||::.:.||:.|:...|||..::.|.|
Mouse   397 EVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/228 (27%)
		Ion_trans_2	221..295	CDD:285168	31/74 (42%)
		KCNQ_channel	<619..719	CDD:281513
Kcna10	NP_001074609.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..44
		BTB_2	88..179	CDD:280393
		BTB	88..171	CDD:197585
		Ion_trans	267..467	CDD:278921	60/203 (30%)
		Ion_trans_2	382..458	CDD:285168	31/75 (41%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900