DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcns3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001162036.1	Gene:	Kcns3 / 238076	MGIID:	1098804	Length:	491	Species:	Mus musculus

Alignment Length:	353	Identity:	91/353 - (25%)
Similarity:	151/353 - (42%)	Gaps:	78/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCL--------ALSVFSTIKEYEEDAVY-- 105
            ::|:.:|:.:::..:|.|.      |.:...|:..:.|        |:.|.|..:...||...
Mouse   161 ELRFGQLRKKIWIRMENPA------YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDD 219

  Fly   106 -ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTS 169
             :|..:||..:.|||.|...||.::..:.         ||.|.|..|||.|:|:.....|.:.|.
Mouse   220 PVLEGVEIACIAWFTGELAIRLVAAPSQK---------KFWKNPLNIIDFVSIIPFYATLAVDTK 275

  Fly   170 ----------GQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGL 224
                      |:|  ...||.:|.|:||::.|  ...|...|..::.:::.:..:..:::. :|:
Mouse   276 EEESEDIENMGKV--VQILRLMRIFRILKLAR--HSVGLRSLGATLRHSYHEVGLLLLFLS-VGI 335

  Fly   225 IFASFLVYMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFAL 288
            ...|.|:|..|||.: ...::.....||..|::.||||||..|:|..||:|||.|.:.||...||
Mouse   336 SIFSVLIYSVEKDEHKSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCIICGILVVAL 400

  Fly   289 PAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRC-------------------YAADEHS 334
            |..|:.:.|:   :..|:||.|            .|.:|                   ||...|:
Mouse   401 PITIIFNKFS---KYYQKQKDM------------EVDQCSEDPPEKCHELPYFNIRDVYAQQVHA 450

  Fly   335 VSVATWNIHRVALPSPPASRASSSFKHN 362
            ...:..:|..|.  |.|.|..:||.:.|
Mouse   451 FITSLSSIGIVV--SDPDSTDASSVEDN 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/218 (29%)
		Ion_trans_2	221..295	CDD:285168	30/74 (41%)
		KCNQ_channel	<619..719	CDD:281513
Kcns3	NP_001162036.1	BTB_POZ_KCNS3	15..122	CDD:349735
		Ion_trans	184..417	CDD:366146	70/249 (28%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810