DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and Kcnq5

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001153611.1	Gene:	Kcnq5 / 226922	MGIID:	1924937	Length:	952	Species:	Mus musculus

Alignment Length:	1055	Identity:	364/1055 - (34%)
Similarity:	480/1055 - (45%)	Gaps:	301/1055 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RMSLLGKPLNY--NRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTI 96
            |||||||||:|  ::..||:|:|||:|:.|||.|||||| .|..||..|||:||.||.|||||||
Mouse    87 RMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRG-WAFVYHAFVFLLVFGCLILSVFSTI 150

  Fly    97 KEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASI 161
            .|:.:.|...|..:|.::::.|.:||..|:||:||..||:|..|||:|.::|||:||.:.::|||
Mouse   151 PEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASI 215

  Fly   162 VVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
            .|:...|.|.:|||||||.|||.|||||||||||||||||||||||||.:||||..|||||.|||
Mouse   216 AVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIF 280

  Fly   227 ASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAG 291
            :|||||:.|||.|.:||.:|.|||||.|||.|:||||..|:||.|:|:::..|||||||||||||
Mouse   281 SSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAG 345

  Fly   292 ILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALP--SP---- 350
            |||||||||||:|.||||..:||.|||.|||.|||.|||||.|||:|||..|..||.  ||
Mouse   346 ILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKE 410

  Fly   351 PASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASV 415
            ....:||.|..|.....|:.|.|: :||.:...   :...::.|.|.|         |:...|||
Mouse   411 QGEASSSKFCSNKQKFFRVYTSRK-QSQKLSFK---ERVRMASPRGQS---------IKSRQASV 462

  Fly   416 ENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQ 480
                    |...:|  |.|..||.:..|..|:                     ..|.||.|.|
Mouse   463 --------GDRRSP--STDITAEGSPTKVQKS---------------------WSFNDRTRFR-- 494

  Fly   481 DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
                                                      .:|.|::.:..|..|.|...|.|
Mouse   495 ------------------------------------------PSLRLKSSQPKPVIDADTALGID 517

  Fly   546 EDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPR 610
             |...:..||                                            .||:.|:
Mouse   518 -DVYDEKGCQ--------------------------------------------CDVSVED---- 533

  Fly   611 CTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQIL 675
               ||...||.||.||.:|:.||:|||||.|:|||||||:|||:|||:|:|.|:|.|..|:||||
Mouse   534 ---LTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIL 595

  Fly   676 GKQGSKAKDVYASKI----------SLASRVVKVERQVADIEEKLDILIKAY------------- 717
            ||....:......||          |:.:||||||:||..||.|||.|:..|
Mouse   596 GKGQMTSDKKSREKITAEHETTDDPSMLARVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALT 660

  Fly   718 --------------------MEDRD-----------------------RFLALP--------LPA 731
                                ::.:|                       :|:..|        ...
Mouse   661 LASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLTRSASANISRGLQFILTPNEFSAQTFYAL 725

  Fly   732 KPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQ--- 793
            .|.:|| ..:..|:......:::........:|..|:....|.|..|  |..|.::.|:..:
Mouse   726 SPTMHS-QATQVPMSQNDGSSVVATNNIANQISAAPKPAAPTTLQIP--PPLSAIKHLSRPEPLL 787

  Fly   794 -TPTTTTDAIATQT----PMPPHVQHTATN-TKS-SVLNSYQLGSEKQQHNDVFMTELENRT--- 848
             .||...::|:..|    .....||...:| ||. |:..|:.:|.|         |.|..|.
Mouse   788 SNPTGLQESISDVTTCLVASKESVQFAQSNLTKDRSLRKSFDMGGE---------TLLSVRPMVP 843

  Fly   849 ----KKRVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLN 909
                |.....:|.|||.|        :.:...|::|..|
Mouse   844 KDLGKSLSVQNLIRSTEE--------LNLQFSGSESSGS-------------------------- 874

  Fly   910 CEGEMDHFPTWE------IDSDIGVEVDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSS 968
             .|..|.:|.|.      .|.::|.| :.:.|..........:.|....:.||       ....|
Mouse   875 -RGSQDFYPKWRESKLFITDEEVGAE-ETETDTFDGTPPPAGEAAFSSDSLRT-------GRSRS 930

  Fly   969 AHNLQQLNDQTTTLN 983
            :.|:.:..|.|..|:
Mouse   931 SQNICKTGDSTDALS 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	130/204 (64%)
		Ion_trans_2	221..295	CDD:285168	50/73 (68%)
		KCNQ_channel	<619..719	CDD:281513	58/142 (41%)
Kcnq5	NP_001153611.1	Ion_trans	161..359	CDD:278921	129/197 (65%)
		Ion_trans_2	275..349	CDD:285168	50/73 (68%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		KCNQ_channel	473..660	CDD:281513	82/303 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..617		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..952		11/57 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1387
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42770
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850