DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and shw-3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001355445.1	Gene:	shw-3 / 191761	WormBaseID:	WBGene00004793	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	78/305 - (25%)
Similarity:	139/305 - (45%)	Gaps:	48/305 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRRLQSRLYNFLERPRG------LHAIFYHVMVFLMVFTCL---------ALSVF--------ST 95
            :::::.|::...:.|..      :.||....::..::..||         .|:.|        ||
Worm   169 WQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLRIPELAPFGNFSRNHRST 233

  Fly    96 IKEYEEDAVYI----------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFC 150
            ........:.|          ...:|.:..||||:|..||.  |.|.||::       :::.|..
Worm   234 SSRIHPAQINIDKANSRPHPTFMYIETICNIWFTIEILARF--SSCPSRFE-------YLRAPVN 289

  Fly   151 IIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELIT 215
            |||||..|...:.|   .|....||:.|......:|:|:.::.......|:|.....|..:||:.
Worm   290 IIDIVATLTFYIDL---LSSMFGATADLEFFSIIRIMRLFKLTHHNSGLKILMHTFRASAKELML 351

  Fly   216 TMYIGFLGLIFASFLVYMWEK---DVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASC 277
            .::...||::..:.|||..|:   :.:::|.:....|||.::|:.|:||||:.|.|:.|:||.|.
Worm   352 LVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAIVTMTTIGYGDITPHTYLGRLIGSI 416

  Fly   278 CALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQ 322
            |||.|:...|||..::.|.||:.....|.:..|.::|:...::.|
Worm   417 CALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSMDQ 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/217 (29%)
		Ion_trans_2	221..295	CDD:285168	29/76 (38%)
		KCNQ_channel	<619..719	CDD:281513
shw-3	NP_001355445.1	BTB_POZ	25..136	CDD:365784
shw-3	NP_001355445.1	Ion_trans	257..444	CDD:366146	63/198 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810