DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kvs-3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_505407.2	Gene:	kvs-3 / 185719	WormBaseID:	WBGene00018402	Length:	451	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	81/291 - (27%)
Similarity:	136/291 - (46%)	Gaps:	51/291 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RLYNFLERPRGLH-AIFYHVMVFLMVFTCLALSVFSTIKEYEE---DAVYILFRMEILVVIWFTM 120
            :||..:|.||... |..:.|...|.|...|...:.|::.|.::   :..|:|..:|:|.:::||.
Worm   167 KLYRLMENPRSSSGAKIFSVGSALFVLLSLLGLILSSMPELQDENKEPHYLLHWLELLCMVYFTF 231

  Fly   121 EFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVF-----------A 174
            |:.|||..:..::         :|::.|..:||::|:|..::        :.|           |
Worm   232 EYLARLLVNPKKA---------EFIRSPLNVIDLLTVLPFMI--------EAFNELQWMKEFRGA 279

  Fly   175 TSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL--GLIFASFLVYMWEKD 237
            ...:|.:|..::.|:.::.|.....:..|..:.....||  :|...||  |::..|..:|.:|:|
Worm   280 MLVVRVMRLARVARIFKLARYSTGLRAFGETMKKSAAEL--SMLGMFLVTGIMLFSTAIYFFERD 342

  Fly   238 -VNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKV 301
             .|.||.:...|.||.|||:.||||||:||||..||::|:..::.||...|.|..::...||...
Worm   343 EPNSKFYSIPAACWWCVITMTTVGYGDLVPITAGGKVVAALASVCGIIVLAFPISMIIDKFAEST 407

  Fly   302 ------QQQQRQKHMIRRR--------QPAA 318
                  ...:.|.|||..|        .|||
Worm   408 GGWSGGDGDEEQGHMIVHRTVHPLNNGAPAA 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	61/227 (27%)
		Ion_trans_2	221..295	CDD:285168	33/76 (43%)
		KCNQ_channel	<619..719	CDD:281513
kvs-3	NP_505407.2	BTB	26..133	CDD:197585
		BTB_2	28..127	CDD:280393
		Ion_trans	206..407	CDD:278921	62/219 (28%)
		Ion_trans_2	324..405	CDD:285168	34/80 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810