DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kvs-2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001256236.1	Gene:	kvs-2 / 183120	WormBaseID:	WBGene00007862	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	323	Identity:	82/323 - (25%)
Similarity:	142/323 - (43%)	Gaps:	70/323 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LYNFLERPRG--LHAIFYHVMVFLMVFTCLALSVFSTIKEYEED----AVYILFR---------- 109
            ::.|||.|:.  ..|:|..:.|| .||..:...:..::.|::.|    |.|.:..
Worm   247 MWKFLEDPQSSVFAAVFALLSVF-FVFASVVGLILGSMPEFQADSSNAATYHVMHVRSRPNDYGN 310

  Fly   110 -------------------------------MEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLK 143
                                           :|.:.:.|||.|:..| ::...|.|        :
Worm   311 KFGNDDDVAPNELLKDFVYKPTDSPNLPLTILEYICIGWFTFEYLVR-FTIYPRKR--------Q 366

  Fly   144 FVKRPFCIIDIVTIL-----ASIVVLGMGTSGQVFATSALRGLRFFQILRMVR---MDRRGGTWK 200
            |||:...|||:.|||     ..:.:.|:.:..:.| |.|:..:|..::|||.|   :.|...:.:
Worm   367 FVKKTLNIIDLSTILPFYLEICLPLFGVESRLKEF-TGAMLVVRVLRVLRMARVFKLARYSTSLQ 430

  Fly   201 LLGSVVYAHRQEL-ITTMYIGFLGLIFASFLVYMWEKD-VNDKFSNFAQALWWGVITLCTVGYGD 263
            ..|..:.:...|| :.:|:: ..|::|.|.::|..||| .:..|.:.....||.|:|:.||||||
Worm   431 TFGHTLQSSITELSMLSMFL-ITGIVFFSTIMYYLEKDEPHTDFYSIPAGCWWCVVTMATVGYGD 494

  Fly   264 MVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWR 326
            ..|:|..|||:|:..::.||...|.|..::...|| ..||:..:...|::.|.:|....|:.|
Worm   495 AKPVTTLGKLVATSTSICGIIVLAFPISMIVEKFA-TAQQRAIEDQQIQQAQMSAVANNALLR 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	66/259 (25%)
		Ion_trans_2	221..295	CDD:285168	28/74 (38%)
		KCNQ_channel	<619..719	CDD:281513
kvs-2	NP_001256236.1	BTB_POZ_Kv	111..199	CDD:349626
kvs-2	NP_001256236.1	Ion_trans	329..535	CDD:366146	63/217 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910