DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and egl-36

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_509795.1	Gene:	egl-36 / 181269	WormBaseID:	WBGene00001202	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	80/316 - (25%)
Similarity:	144/316 - (45%)	Gaps:	47/316 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERP---------RGLHAIFYHVMVFLMVFT- 86
            |..|...|...:|.:|.|  .|:.:|:.::::..:.|         .|:..:|    :|:.:|:
Worm   163 QDTMKKFGWEEDYFQGKR--TRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLF----IFISIFSF 221

  Fly    87 CLALS-------------------VFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCR 132
            ||...                   |..:|:....:.:.|..::|:|..||||:|.         .
Worm   222 CLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLEL---------I 277

  Fly   133 SRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGG 197
            .|:..|..:::|.|.|..:||:|..|:......|....:......:..|...:|.|:.::.:...
Worm   278 IRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPKDVVEFLSMIRIFRLFKLTQHHQ 342

  Fly   198 TWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEK---DVNDKFSNFAQALWWGVITLCTV 259
            ..::|.....|..:|||..::...||::..:.|||..||   :.|::|.:....|||.:.|:.||
Worm   343 GLQILIHTFRASAKELILLVFFLILGIVIFAALVYYAEKMEANPNNQFQSIPLGLWWAICTMTTV 407

  Fly   260 GYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQ 315
            |||||.|.|..|:|:.|.||::|:...|||..::.|.||:.....|.:..:.:||:
Worm   408 GYGDMTPHTSFGRLVGSLCAVMGVLTIALPVPVIVSNFAMFYSHNQARDKLPKRRR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	60/207 (29%)
		Ion_trans_2	221..295	CDD:285168	31/76 (41%)
		KCNQ_channel	<619..719	CDD:281513
egl-36	NP_509795.1	BTB	39..132	CDD:197585
		BTB_2	39..129	CDD:280393
		Ion_trans	254..451	CDD:278921	60/205 (29%)
		Ion_trans_2	369..451	CDD:285168	32/81 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810