DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and kqt-1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_741819.1	Gene:	kqt-1 / 180933	WormBaseID:	WBGene00002233	Length:	740	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	299/685 - (43%)
Similarity:	394/685 - (57%)	Gaps:	146/685 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKE 98
            :|||:||||.| :..|.|.|:||:|::::||||||||..|..||:.|..||..|||||||||:.:
Worm   111 KMSLVGKPLTY-KNYRTDQRFRRMQNKMHNFLERPRGWKAATYHLAVLFMVLMCLALSVFSTMPD 174

  Fly    99 YEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVV 163
            :|.:|..:|:.:||:.|||...|:..|:||:||||||:|..||::|....:|:|||:.|||||.|
Worm   175 FEVNATIVLYYLEIVFVIWLATEYICRVWSAGCRSRYRGISGRIRFATSAYCVIDIIVILASITV 239

  Fly   164 LGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFAS 228
            |.:|.:|||||.||:|||||||||||:|:|||.||||||||||:||||||:||:|||||||||:|
Worm   240 LCIGATGQVFAASAIRGLRFFQILRMLRIDRRAGTWKLLGSVVWAHRQELLTTVYIGFLGLIFSS 304

  Fly   229 FLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL 293
            ||||:.||:.|||:..||.|||||||||.||||||..|.||.||:||:.||||||||||||||||
Worm   305 FLVYLCEKNTNDKYQTFADALWWGVITLSTVGYGDKTPETWPGKIIAAFCALLGISFFALPAGIL 369

  Fly   294 GSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSS 358
            ||||||||||.|||||:||||.|||.|||.:||.|:|...|.|:|||.|| :|...||..:.:.:
Worm   370 GSGFALKVQQHQRQKHLIRRRVPAAKLIQCLWRHYSAAPESTSLATWKIH-LARELPPIVKLTPN 433

  Fly   359 FKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQN 423
            ..:|.:.:     |.|.:..|.:||                            |.:.:||.|  |
Worm   434 GSNNATGL-----INRLRQSTKRTP----------------------------NLNNQNLAV--N 463

  Fly   424 GKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEG 488
            .::.:.:.|...|.:|..|  :..||.|:...|.  .|..|.|
Worm   464 SQATSKNLSVPRVHDTISL--VSTSDISEIEQLG--ALGFSLG---------------------- 502

  Fly   489 EGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDT 553
                .:.::|.|||::.....|                |::..:||:|     |..||:|.
Worm   503 ----WKSKSKYGGSKKATDDSV----------------LQSRMLAPSN-----AHLDEEEA---- 538

  Fly   554 CQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPRCTQLTNRH 618
                                                 .|: .|..|     ||..|..
Worm   539 -------------------------------------VGY-QPQTI-----EEFTPAL------- 553

  Fly   619 KTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKAK 683
            |..:|.||:::..|||:||||||||||||||:|||:||||||..|||.:..:||.|.||...|.:
Worm   554 KNCVRAIRRIQLLVARKKFKEALKPYDVKDVIEQYSAGHVDLQSRVKTVQAKLDFICGKNIEKIE 618

  Fly   684 DVYASKISLASRVVKVERQVADIEEKLDILIKAYM 718
                .|||:.:|:..:|..|..:::|||::::..|
Worm   619 ----PKISMFTRIATLETTVGKMDKKLDLMVEMLM 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	143/204 (70%)
		Ion_trans_2	221..295	CDD:285168	56/73 (77%)
		KCNQ_channel	<619..719	CDD:281513	49/100 (49%)
kqt-1	NP_741819.1	Ion_trans	173..379	CDD:278921	141/205 (69%)
		Ion_trans_2	297..371	CDD:285168	56/73 (77%)
		KCNQ_channel	<540..651	CDD:281513	55/127 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159239
Domainoid	1	1.000	316	1.000	Domainoid score	I684
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I665
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	1	1.000	-	-		FOG0003178
OrthoInspector	1	1.000	-	-		oto19782
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930