DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and shl-1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_500975.2	Gene:	shl-1 / 177400	WormBaseID:	WBGene00022240	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	471	Identity:	120/471 - (25%)
Similarity:	196/471 - (41%)	Gaps:	104/471 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPR--GLHAIFYHV 78
            ||.|   .|.|.||:.:.|:.      |.:..|.:    ..|:.:::...|.|.  .:..:||:|
Worm   142 YKDK---KRENQERLQEERVE------NADISTLK----LSLKEKMWAAFENPHTTSIALVFYYV 193

  Fly    79 MVFLMVFTCLALSVFSTIKE-----------------YEEDAVYILFRMEILVVIWFTMEFGARL 126
            :.|.     :|:||...|.|                 |||.    .|.::...||.||:|:..||
Worm   194 IGFF-----IAVSVMCNIVETIPCGYEDNVSVTCGEAYEEQ----FFVIDTACVIIFTIEYFLRL 249

  Fly   127 WSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL---ASIVVLGMGTSGQVFATSALRGLRFFQILR 188
            .|:.         .|:||::....:||::.|:   .|:|:........:|.|     ||.|::.|
Worm   250 ISAP---------DRIKFMRSIMSVIDVIAIMPYYVSLVLTDNKDVSGLFVT-----LRVFRVFR 300

  Fly   189 MVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLG-------LIFASFLVYMWEKDVNDKFSNFA 246
            :.:..|.....::||..:.:...||      |||.       :|||:.:.|..:|....:|::..
Worm   301 IFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIFATIMYYAEKKVDATRFTSIP 359

  Fly   247 QALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMI 311
            .|.|:.::||.|:|||||||.|..||::...|:|.|:...|||..::.|.|:....|.||...
Worm   360 SAFWYTIVTLTTLGYGDMVPSTIMGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADK-- 422

  Fly   312 RRRQPAATL--IQAVWRCYAADEHSVSVATWN---IHRVAL-------PSPPASRASSSFK---H 361
            |:.|..|.|  |:.|       :::..:|.:|   .|...:       .|..|.|....|:   |
Worm   423 RKAQKKARLARIRIV-------KNASGLALFNKKRAHEARMLAFEQGHLSFDALRDEDIFEIQHH 480

  Fly   362 NTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRAST--RYTRTIRDINASVENLEVVQNG 424
            :........|.|......:...||.     :.||.|..||.  :..|..|....|.||.|:.:..
Worm   481 HLLQCLEKATEREFVESEVMFEGGR-----NTPPPSETASLKGKTKRKRRLCCVSKENEEMEELD 540

  Fly   425 KSMNPSFSE--DSVAE 438
            :....:|::  |.:.|
Worm   541 RETRVTFNQNMDQICE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/214 (29%)
		Ion_trans_2	221..295	CDD:285168	29/80 (36%)
		KCNQ_channel	<619..719	CDD:281513
shl-1	NP_500975.2	BTB_POZ	6..149	CDD:365784	4/9 (44%)
		Ion_trans	187..416	CDD:366146	72/257 (28%)
		DUF3399	460..528	CDD:371777	16/72 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810