DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNG3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_579875.1	Gene:	KCNG3 / 170850	HGNCID:	18306	Length:	436	Species:	Homo sapiens

Alignment Length:	334	Identity:	79/334 - (23%)
Similarity:	131/334 - (39%)	Gaps:	77/334 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFY--DIRGYKGK--CRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLY 62
            |..:|.|.||  |..|..|:  .|||...:                        ...||...|:.
Human   118 DRMSDTYTFYSADEPGVLGRDEARPGGAEA------------------------APSRRWLERMR 158

  Fly    63 NFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEY----------------------EEDA 103
            ...|.|....|  |...|.|..::.:.:.|.. ||:.::                      |...
Human   159 RTFEEPTSSLAAQILASVSVVFVIVSMVVLCA-STLPDWRNAAADNRSLDDRSRYSAGPGREPSG 222

  Fly   104 VYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTI----LASIVVL 164
            :     :|.:.:.|||.|         |..|:.....:.:|||||..|||::.|    ::.::.:
Human   223 I-----IEAICIGWFTAE---------CIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTV 273

  Fly   165 GMGTSGQV-FATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFAS 228
            ..|.:.|: .|...||.||..:|..::::.|.....:.||..:....:|::..:....:.:...|
Human   274 FTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFS 338

  Fly   229 FLVYMWEKDV-----NDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFAL 288
            .|..:.|..:     |..|::...|.||.:|::.|||||||.|||..|:::...|.:.||...||
Human   339 ALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLAL 403

  Fly   289 PAGILGSGF 297
            |...:...|
Human   404 PITFIYHSF 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	56/208 (27%)
		Ion_trans_2	221..295	CDD:285168	26/78 (33%)
		KCNQ_channel	<619..719	CDD:281513
KCNG3	NP_579875.1	BTB_POZ_KCNG3	11..122	CDD:349729	1/3 (33%)
		Ion_trans	219..420	CDD:395416	56/208 (27%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	373..378		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810