Protein Alignment KCNQ and KCNG3

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_579875.1
• Gene: KCNG3 / 170850
• HGNCID: 18306
• Length: 436
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 79/334 - (23%)
• Similarity: 131/334 - (39%)
• Gaps: 77/334 - (23%)

  Fly     2 DPDNDIYAFY--DIRGYKGK--CRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLY 62
            |..:|.|.||  |..|..|:  .|||...:                        ...||...|:.
Human   118 DRMSDTYTFYSADEPGVLGRDEARPGGAEA------------------------APSRRWLERMR 158

  Fly    63 NFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEY----------------------EEDA 103
            ...|.|....|  |...|.|..::.:.:.|.. ||:.::                      |...
Human   159 RTFEEPTSSLAAQILASVSVVFVIVSMVVLCA-STLPDWRNAAADNRSLDDRSRYSAGPGREPSG 222

  Fly   104 VYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTI----LASIVVL 164
            :     :|.:.:.|||.|         |..|:.....:.:|||||..|||::.|    ::.::.:
Human   223 I-----IEAICIGWFTAE---------CIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTV 273

  Fly   165 GMGTSGQV-FATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFAS 228
            ..|.:.|: .|...||.||..:|..::::.|.....:.||..:....:|::..:....:.:...|
Human   274 FTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFS 338

  Fly   229 FLVYMWEKDV-----NDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFAL 288
            .|..:.|..:     |..|::...|.||.:|::.|||||||.|||..|:::...|.:.||...||
Human   339 ALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLAL 403

  Fly   289 PAGILGSGF 297
            |...:...|
Human   404 PITFIYHSF 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	63/260 (24%)
		KCNQ_channel	<619..719	CDD:460954
KCNG3	NP_579875.1	BTB_POZ_KCNG3	11..122	CDD:349729	1/3 (33%)
		Ion_trans	219..420	CDD:459842	56/208 (27%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	373..378		4/4 (100%)