DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and Kcnq2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_038960105.1	Gene:	Kcnq2 / 170848	RGDID:	621504	Length:	937	Species:	Rattus norvegicus

Alignment Length:	1041	Identity:	339/1041 - (32%)
Similarity:	463/1041 - (44%)	Gaps:	295/1041 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PGRPNSER---IL------QPRMSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHA 73
            ||.|:|.|   :|      ..|.|:|.||.....|.    :|:..||:||:.|||.|||||| .|
  Rat    29 PGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG-WA 92

  Fly    74 IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGC 138
            ..||..|||:||:||.|||||||||||:.:...|:.:||:.::.|.:|:..|:|::||..||:|.
  Rat    93 FIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGW 157

  Fly   139 LGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLG 203
            .|||||.::|||:|||:.::|||.||..|:.|.||||||||.|||.|||||:|||||||||||||
  Rat   158 RGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLG 222

  Fly   204 SVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPIT 268
            ||||||.:||:|..|||||.||.||||||:.||..||.|..:|.|||||:|||.|:||||..|.|
  Rat   223 SVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQT 287

  Fly   269 WQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEH 333
            |.|:|:|:...|:|:|||||||||||||||||||:|.||||..:||.|||.|||:.||.||.
  Rat   288 WNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYAT--- 349

  Fly   334 SVSVATWNIHRVALPSPPASRASSSFKHNT-SFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGS 397
                   |:.|..|             |:| .:..|..|:..:.||| ||.|.
  Rat   350 -------NLSRTDL-------------HSTWQYYERTVTVPMYSSQT-QTYGA------------ 381

  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNP-SFSEDSVAETT---------CLKNIKNSDASQ 452
                   :|.|..:|    .||:::|.||.:. :|.::...|.:         ||.......:||
  Rat   382 -------SRLIPPLN----QLELLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGCLCGCCPGHSSQ 435

  Fly   453 PATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLH 517
            ..:|.:...||..|                            ..||..||.:..|:
  Rat   436 KVSLKDRVFSSPRG----------------------------VAAKGKGSPQAQTV--------- 463

  Fly   518 GNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFF 582
                         |.:|:.|:.|:                         ||||..|.|...|...
  Rat   464 -------------RRSPSADQSLD-------------------------DSPSKVPKSWSFGDRS 490

  Fly   583 AAASHFLETGFSSPN-------PIIDVANEEDEPRCT------QLTNRHKTAIRFIRKLKYFVAR 634
            .|...|...|.:|..       |..|:.  ||...|.      .||...|.:||.:..:::.|::
  Rat   491 RARQAFRIKGAASRQNSEEASLPGEDIV--EDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSK 553

  Fly   635 RKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHL------------------------------ 669
            |||||:|:||||.||:|||:|||:|:|.|:|.|..
  Rat   554 RKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRQEPLPVQSGHEQGPPGQNQAWHKGHQGLG 618

  Fly   670 -RLDQILG-------------KQG----SKAKDVYASKI-------------------------- 690
             |:|.|:|             .:|    |:....|:.::
  Rat   619 DRIDMIVGPPPPSTPRHKKYPTKGPTAPSRESPQYSPRVDQIVGRGPTITDKDRTKGPAETELPE 683

  Fly   691 --SLASRVVKVERQVADIEEKLDILIKAYME-------DRDRFLAL--PLPAKPKIHSISPSHKP 744
              |:..|:.|||:||..:|:|||.|:..|.:       :.:.:...  |.|| |..|  ||....
  Rat   684 DPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPA-PPYH--SPEDSR 745

  Fly   745 LHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPS--APDSSELRSLTATQTPTTTTDAIATQTP 807
            .|...:..:|.:.:.|:  |.........|::.|:  .|.:|..:|.....|..........:.|
  Rat   746 DHADKHGCIIKIVRSTS--STGQRNYAAPPVMPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVRIP 808

  Fly   808 MPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELEN----RTKKRVTLSLHRSTSEPYSKQE 868
            .||..:.:        |::|..|:.....    ...||.    |..:........|.|.|....|
  Rat   809 PPPAHERS--------LSAYSGGNRASTE----FLRLEGTPACRPSEAALRDSDTSISIPSVDHE 861

  Fly   869 Q--------RITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSD 925
            :        .|:...|..|:|.|......|.:.:           .....|||.|      .|||
  Rat   862 ELERSFSGFSISQSKENLDALASCYAAVAPCAKV-----------RPYIAEGESD------TDSD 909

  Fly   926 I 926
            :
  Rat   910 L 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	128/204 (63%)
		Ion_trans_2	221..295	CDD:285168	47/73 (64%)
		KCNQ_channel	<619..719	CDD:281513	47/175 (27%)
Kcnq2	XP_038960105.1	Ion_trans	92..324	CDD:395416	148/231 (64%)
		KCNQ_channel	466..719	CDD:397540	68/279 (24%)
		KCNQ2_u3	734..821	CDD:406935	20/99 (20%)
		KCNQC3-Ank-G_bd	833..933	CDD:403240	20/95 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1342
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1440
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44832
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970