Protein Alignment KCNQ and Kcnq1

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_006508551.2
• Gene: Kcnq1 / 16535
• MGIID: 108083
• Length: 688
• Species: Mus musculus
• Alignment Length: 731
• Identity: 264/731 - (36%)
• Similarity: 358/731 - (48%)
• Gaps: 224/731 - (30%)

  Fly    25 PNSERILQPRMSLLGKPLNYNRGTRRDVRYR-RLQSRLYNFLERPRGLHAIFYHVMV-------- 80
            |.....|.||:|:.        ..||.:..| .:|.|:|||||||.|.....||..|
Mouse    80 PRPRVSLDPRVSIY--------SARRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVPGTMHQLP 136

  Fly    81 ------------FLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRS 133
                        ||:|..||..||.|||::|...|...||.|||::|::|..|:..||||:||||
Mouse   137 TSILIPKNMPGGFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRS 201

  Fly   134 RYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGT 198
            :|.|..|||:|.::|..|||::.::||:|||.:|:.||||||||:||:||.|||||:.:||:|||
Mouse   202 KYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGT 266

  Fly   199 WKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKD-VND----KFSNFAQALWWGVITLCT 258
            |:||||||:.||||||||:|||||||||:|:.||:.||| ||:    :|.::|.||||||:|:.|
Mouse   267 WRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTT 331

  Fly   259 VGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQA 323
            :||||.||.||.||.||||.::..|||||||||||||||||||||:|||||..|:...||:|||.
Mouse   332 IGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQT 396

  Fly   324 VWRCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDG 388
            .||||||:  :...|||.|:                       .|.|.    :|.|:.:|.
Mouse   397 AWRCYAAE--NPDSATWKIY-----------------------VRKPA----RSHTLLSPS---- 428

  Fly   389 GGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQP 453
               .||..|.....:..:..:|            ||  |:|
Mouse   429 ---PKPKKSVMVKKKKFKLDKD------------NG--MSP------------------------ 452

  Fly   454 ATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHG 518
                                              ||              :...:|.:.|.
Mouse   453 ----------------------------------GE--------------KMFNVPHITYD---- 465

  Fly   519 NFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPD--SPSGSPGSGRTGRF 581
                           |..||                          :||  |..|...|.|....
Mouse   466 ---------------PPEDR--------------------------RPDHFSIDGYDSSVRKSPT 489

  Fly   582 FAAAS--HFLETGFSSPNPIIDVANEEDEPRCT------QLTNRHKTAIRFIRKLKYFVARRKFK 638
            ....|  |||.|     |...:..:.|.|...|      ||.:.|:..|:.||:::||||::||:
Mouse   490 LLEVSTPHFLRT-----NSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQ 549

  Fly   639 EALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQ------GSKAKDVYASKISLASRVV 697
            :|.|||||:||:|||:.||::|:.|:|.|..||||.:||.      ..|:||  ....::.:|:.
Mouse   550 QARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKD--RGSNTIGARLN 612

  Fly   698 KVERQVADIEEKLDIL 713
            :||.:|..::::|.|:
Mouse   613 RVEDKVTQLDQRLVII 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	132/209 (63%)
		Ion_trans_2	221..295	CDD:285168	49/78 (63%)
		KCNQ_channel	<619..719	CDD:281513	41/101 (41%)
Kcnq1	XP_006508551.2	Ion_trans	149..378	CDD:366146	143/228 (63%)
		KCNQ_channel	<530..636	CDD:367540	41/101 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	1	1.000	-	-		FOG0003178
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.760