DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNQ and Kcnd2

DIOPT Version :9

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_062671.1 Gene:Kcnd2 / 16508 MGIID:102663 Length:630 Species:Mus musculus


Alignment Length:457 Identity:129/457 - (28%)
Similarity:194/457 - (42%) Gaps:96/457 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 QSRLYNFLERPR--GLHAIFYHVMVFLMVFTCLALSVFST---------IKEY---EEDAVYILF 108
            :.|::...|.|.  .:..:||:|..|.:..:.:| :|..|         |||.   |..|| ..|
Mouse   168 RQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIA-NVVETVPCGSSPGHIKELPCGERYAV-AFF 230

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVF 173
            .::...|:.||:|:..||  :...|||       :||:....|||:|.||...:.|.|..:..| 
Mouse   231 CLDTACVMIFTVEYLLRL--AAAPSRY-------RFVRSVMSIIDVVAILPYYIGLVMTDNEDV- 285

  Fly   174 ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFLV 231
             :.|...||.|::.|:.:..|.....::||..:.:...||      |||       .:|||:.:.
Mouse   286 -SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVMF 343

  Fly   232 YMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSG 296
            |..:.....||::...|.|:.::|:.|:|||||||.|..||:..|.|:|.|:...|||..::.|.
Mouse   344 YAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSN 408

  Fly   297 FALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPS--------PPA- 352
            |:....|.||...  ||.|..|.|.    |..||...|.: |.....|..|.|        .|| 
Mouse   409 FSRIYHQNQRADK--RRAQKKARLA----RIRAAKSGSAN-AYMQSKRNGLLSNQLQSSEDEPAF 466

  Fly   353 -SRASSSFK-------H------NTSFV---------ARLPTIRRHKSQTIQTPGGGDGGGVSKP 394
             |::.|||:       |      |..||         ..:.|:.|..|   .:|......||:  
Mouse   467 ISKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSS---HSPSLSSQQGVT-- 526

  Fly   395 PGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKN--IKNSDASQPATLA 457
              |:..|.|:.:|.|..||:|..        |...|..|.|..:..|::.  :.||.:|..|.:.
Mouse   527 --STCCSRRHKKTFRIPNANVSG--------SHRGSVQELSTIQIRCVERTPLSNSRSSLNAKME 581

  Fly   458 NC 459
            .|
Mouse   582 EC 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 100..305 CDD:278921 67/211 (32%)
Ion_trans_2 221..295 CDD:285168 29/80 (36%)
KCNQ_channel <619..719 CDD:281513
Kcnd2NP_062671.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
Shal-type 3..28 CDD:288455
BTB 43..140 CDD:197585
BTB_2 43..132 CDD:280393
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90
Ion_trans 216..415 CDD:278921 69/216 (32%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321 2/12 (17%)
Ion_trans_2 331..411 CDD:285168 29/79 (37%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 3/4 (75%)
DUF3399 445..546 CDD:288712 26/107 (24%)
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881 474..630 29/125 (23%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 2/14 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..623
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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