DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNQ and Kcnb1

DIOPT Version :9

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_032446.2 Gene:Kcnb1 / 16500 MGIID:96666 Length:857 Species:Mus musculus


Alignment Length:770 Identity:170/770 - (22%)
Similarity:273/770 - (35%) Gaps:228/770 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFRMEIL 113
            :.:|::.||:|....|  |...:.:..:|.:.:|||: :|:.|.:....:       .|..:|.:
Mouse   172 RKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL-NTLPELQSLDEFGQSTDNPQLAHVEAV 235

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||||:..|..||.         .:.||.|.|...||::.||...|.:.:..|.        
Mouse   236 CIAWFTMEYLLRFLSSP---------KKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQN 291

  Fly   171 -----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFL 230
                 |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.|
Mouse   292 VRRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL 348

  Fly   231 VYMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            |:..|||.:| ||.:...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.
Mouse   349 VFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413

  Fly   295 SGFALKVQQQQRQKHMIRRRQPA------ATLI-----------------------QAVWRCYAA 330
            :.|:...::|:||:..|:||:..      .:::                       :.|.:....
Mouse   414 NNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGEGVAKKDKV 478

  Fly   331 DEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPP 395
            .::.:|...|...:.||     |..|||....|            |.|          |...|..
Mouse   479 QDNHLSPNKWKWTKRAL-----SETSSSKSFET------------KEQ----------GSPEKAR 516

  Fly   396 GSSRASTRYTRTIRDINASVENL--EVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLA- 457
            .||.......:.::|:.:.:...  :.:.|.|.|.|........|.          .|.|:.:| 
Mouse   517 SSSSPQHLNVQQLQDMYSKMAKTQSQPILNTKEMAPQSQPQEELEM----------GSMPSPVAP 571

  Fly   458 ---------NCKLSSSAGSL----AQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIP 509
                     :.:..||..|.    ..||:..|          ......|....|:|||    |.|
Mouse   572 LPTRTEGVIDMRSMSSIDSFISCATDFPEATR----------FSHSPLASLSGKSGGS----TAP 622

  Fly   510 VVLY-GFLHGNFLGSTLSLRNPRVAPANDRD---LEAGRDEDEVHKDTCQRS---NTL---PLPV 564
            .|.: |.|..:  |..|...||  .|...|.   :|:.|...:.|.....|:   |.|   |.|:
Mouse   623 EVGWRGALGAS--GGRLMETNP--IPEASRSGFFVESPRSSMKTHNPMKLRALKVNFLEGDPTPL 683

  Fly   565 KP-----DSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIID-------VANEEDEPRCTQLTNR 617
            .|     ..|..:.|..      |||...||.......|::.       .|:....||..:   :
Mouse   684 LPALGLYHDPLRNRGGA------AAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPE---K 739

  Fly   618 HKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQGSKA 682
            | |||.|           .|:..         :.||.....|..|::         :.....|..
Mouse   740 H-TAIAF-----------NFEAG---------VHQYIDTDTDDEGQL---------LYSVDSSPP 774

  Fly   683 KDVYAS---KISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPK 734
            |.::.|   |.||.:|.                       :::.|.:.|||..||
Mouse   775 KSLHGSTSPKFSLGART-----------------------EKNHFESSPLPTSPK 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 100..305 CDD:278921 62/225 (28%)
Ion_trans_2 221..295 CDD:285168 30/74 (41%)
KCNQ_channel <619..719 CDD:281513 16/102 (16%)
Kcnb1NP_032446.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
BTB_POZ_KCNB2 15..141 CDD:349719
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 59..75
Ion_trans 188..424 CDD:366146 69/253 (27%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 377..382 4/4 (100%)
Self-association. /evidence=ECO:0000250|UniProtKB:P15387 448..481 1/32 (3%)
Kv2channel 467..678 CDD:367541 53/265 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..569 23/130 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..627 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..802 9/56 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..857
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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