DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcna4

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_067250.2	Gene:	Kcna4 / 16492	MGIID:	96661	Length:	654	Species:	Mus musculus

Alignment Length:	397	Identity:	96/397 - (24%)
Similarity:	158/397 - (39%)	Gaps:	103/397 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|....:
Mouse   214 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALL 268

  Fly    53 RYR-----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFS 94
            ::|                 ..:.:::...|.|      ||:..:...|::..:|..||     .
Mouse   269 KFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCL-----E 328

  Fly    95 TIKEYEEDAVYIL-------------------------------FRMEILVVIWFTMEFGARLWS 128
            |:.|:.:|...|:                               |.:|.:.::||:.||..|.::
Mouse   329 TLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFA 393

  Fly   129 SGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM----------GTSGQVFATSALRGLRF 183
                     |..:..|.|....|||||:||...:.||.          |...|..:.:.||.:|.
Mouse   394 ---------CPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRL 449

  Fly   184 FQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKD-VNDKFSNFAQ 247
            .::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..|.| ....|.:...
Mouse   450 VRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPD 514

  Fly   248 ALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIR 312
            |.||.|:|:.|||||||.|||..||::.|.||:.|:...|||..::.|.|.....::...:...:
Mouse   515 AFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQ 579

  Fly   313 RRQPAAT 319
            ..|.|.:
Mouse   580 LTQNAVS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	68/246 (28%)
		Ion_trans_2	221..295	CDD:285168	33/74 (45%)
		KCNQ_channel	<619..719	CDD:281513
Kcna4	NP_067250.2	K_channel_TID	1..>37	CDD:369607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..145
		BTB_POZ	177..304	CDD:365784	18/99 (18%)
		Ion_trans	307..571	CDD:366146	76/277 (27%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	463..476		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	525..530		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654
		PDZ-binding. /evidence=ECO:0000250	652..654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810