DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcns3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_031758930.1	Gene:	kcns3 / 100497261	XenbaseID:	XB-GENE-952059	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	275	Identity:	77/275 - (28%)
Similarity:	133/275 - (48%)	Gaps:	37/275 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VRYRRLQSRLYNFLERPR-GLHAIFYHVMVFLMVFTCLALSVFSTIKEYE---------EDAVYI 106
            :::..::.:::..||.|. .|.|..:.:....:|.|.:......::.|::         ||.|
Frog   163 LKFGDIRRKIWIRLENPAYSLSAKLFAIASLSVVLTSIVAMCIHSMPEFKKLDANDRELEDPV-- 225

  Fly   107 LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL---ASIVV----- 163
            |..:||:.:||||.|...||..:..:.         ||.|.|..|||.|:|:   |::||
Frog   226 LAVVEIVCIIWFTSELVIRLIVAPSQK---------KFWKNPMNIIDFVSIIPFYATLVVDVNDE 281

  Fly   164 --LGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
              .|:...|:|  ...||.:|.|:||::.|  ...|...|..::.:::.:..:..:::. :|:..
Frog   282 ENEGIENMGKV--VQILRLMRIFRILKLAR--HSVGLRSLGATLKHSYHEVGLLLLFLA-VGISI 341

  Fly   227 ASFLVYMWEKDVNDK-FSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            .|.|||..|||.:.. ..:.....||..|::.||||||..|:|..|||:.:.|.:.||...|||.
Frog   342 FSVLVYYVEKDEDQSGLHSIPMCWWWATISMTTVGYGDTHPVTLFGKLVGTVCIICGILVVALPI 406

  Fly   291 GILGSGFALKVQQQQ 305
            .|:.:.|:...|:|:
Frog   407 TIIFNKFSKYYQKQK 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	68/224 (30%)
		Ion_trans_2	221..295	CDD:285168	29/74 (39%)
		KCNQ_channel	<619..719	CDD:281513
kcns3	XP_031758930.1	BTB_POZ_KCNS3	15..122	CDD:349735
kcns3	XP_031758930.1	Ion_trans	185..421	CDD:395416	72/251 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910