DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcnc4

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_002933043.1	Gene:	kcnc4 / 100492941	XenbaseID:	XB-GENE-6032635	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	96/381 - (25%)
Similarity:	157/381 - (41%)	Gaps:	79/381 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHA----IFYHVMVFLMVFTCLALSVF 93
            |.:..:.:..:.:||.     ::..|.:::...|.|....|    .|..:...||..|...|...
Frog   167 PELLCIEERTDRSRGC-----WKVWQPKMWALFEDPYSSRAARVVAFVSLFFILMSITTFCLETH 226

  Fly    94 ST---------------------IKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQG 137
            .:                     ::|.|.:.  ||..:|.:.|.|||:||..|:.   |
Frog   227 ESFIVDRNVTETVTIGNMTEILVVREVETEP--ILTYIEGVCVFWFTLEFLVRII---C------ 280

  Fly   138 CLGRLKFVKRPFCIIDIVTILASIVVLGM-GTSGQVF--ATSALRGLRFFQILRMVRMDRRGGTW 199
            |..::.|||....|||.|.||...:.:|: |.|.:..  ....||.:||.:|||:.::.|.....
Frog   281 CPDKVFFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGL 345

  Fly   200 KLLGSVVYAHRQELITTMYIGFLG-LIFASFLVYMWEKDVN---------DKFSNFAQALWWGVI 254
            ::||..:.|...|.:..:....|| ||||:.:.|......|         ..|.|.....||.|:
Frog   346 RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPTDPSGSNHTHFKNIPIGFWWAVV 410

  Fly   255 TLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL----GSGFALKVQQQ----QRQKHMI 311
            |:.|:|||||.|.||.|.|:.:.|||.|:...|:|..::    |..::|.:.:|    :::||:.
Frog   411 TMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHVP 475

  Fly   312 RRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPS---PPASRASSSFKHNTS 364
            :..|              .|..:...:..|.||.:..|   |.|:...:..|.:.|
Frog   476 KTSQ--------------MDSQTTLKSEDNSHRNSTQSDTCPLAAEELTEKKRSDS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	71/225 (32%)
		Ion_trans_2	221..295	CDD:285168	31/87 (36%)
		KCNQ_channel	<619..719	CDD:281513
kcnc4	XP_002933043.1	Potassium_chann	1..29	CDD:314363
		BTB_POZ	34..150	CDD:365784
		Ion_trans	203..461	CDD:366146	76/268 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910