DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and kcnq5

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_002937201.3	Gene:	kcnq5 / 100488199	XenbaseID:	XB-GENE-989511	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	1059	Identity:	380/1059 - (35%)
Similarity:	512/1059 - (48%)	Gaps:	274/1059 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IRGYKG----KCRPGRPNSERILQPRMSLLGKPLNYN--RGTRRDVRYRRLQSRLYNFLERPRGL 71
            :||..|    ..|.|:..:      |||||||||:||  :..||:|:||:||:.|||.||||||
Frog    65 VRGGAGGVLHDSRRGKQGA------RMSLLGKPLSYNSSQSCRRNVKYRKLQNYLYNVLERPRG- 122

  Fly    72 HAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQ 136
            ....|||.|||:||:||.|||||||.|:::.|.|.||.:|.::::.|.:|:..|:||:||..||:
Frog   123 WGFVYHVFVFLLVFSCLILSVFSTIPEHQDHASYCLFVLEFVMIVVFGLEYIIRIWSAGCCCRYR 187

  Fly   137 GCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKL 201
            |..|||:|.::|||:|||:.::||:.|:..||.|.:|||||||.|||.|||||||||||||||||
Frog   188 GWQGRLRFARKPFCVIDIIVLIASVAVVSAGTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKL 252

  Fly   202 LGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVP 266
            ||||||||.:||||..|||||.|||:|||||:.||:.|.:|..:|.|||||.|||.|:||||..|
Frog   253 LGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKEANSQFQTYADALWWGTITLTTIGYGDKTP 317

  Fly   267 ITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAAD 331
            .:|.|:|:::..||||||||||||||||||||||||:|.||||..:||.|||:|||.|||.||||
Frog   318 QSWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAASLIQCVWRSYAAD 382

  Fly   332 EHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPG 396
            |.|||:|||..|..||             |..|     ||   .|.|       |:..|......
Frog   383 EKSVSIATWKPHLKAL-------------HTCS-----PT---KKEQ-------GEASGSKLCSN 419

  Fly   397 SSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKL 461
            ..:....||                    |..||                            .||
Frog   420 KQKLFRMYT--------------------SRKPS----------------------------QKL 436

  Fly   462 SSSAGSLAQFPDRNR---DRDQDRRGHGEGEGDQAEEQAKAG--GSRRNLTIPVVL---YGFLHG 518
            |        |.:|.|   .|.|..:|.....||:....|...  ||      |..:   :.|...
Frog   437 S--------FKERVRMASPRGQSIKGRQTSAGDRRSPSADVATDGS------PTKVQKSWSFNDR 487

  Fly   519 NFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDT-CQRSNTLPLPVKPDSPSGSPGSGRTGRFF 582
            .....:|.|::.:..|..|.|:..|  .||||.:. |.
Frog   488 TRFRPSLRLKSSQPKPVTDPDVSLG--ADEVHDEKGCH--------------------------- 523

  Fly   583 AAASHFLETGFSSPNPIIDVANEEDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVK 647
                             .||:.|:       ||...||.||.||.:|:.||:|||||.|:|||||
Frog   524 -----------------CDVSVED-------LTPALKTVIRAIRIMKFHVAKRKFKETLRPYDVK 564

  Fly   648 DVMEQYAAGHVDLLGRVKMLHLRLDQILGK----QGSKAKDVYASKI------SLASRVVKVERQ 702
            ||:|||:|||:|:|.|:|.|..|:||||||    ...|:::...|:|      |:..||||||:|
Frog   565 DVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQISTDKKSREKNPSEIEAGDDLSMLGRVVKVEKQ 629

  Fly   703 VADIEEKLDILIKAYMEDRDR---------FLALPL-----------PAKPKIHSISPSHKPLHH 747
            |..||.|||.|:..|.:...:         .|.:||           |...|  .:|.|
Frog   630 VQSIESKLDSLLDIYQQVLKKGSASALTLASLQMPLFECEQTSDYQSPTDGK--DVSNS------ 686

  Fly   748 AHNLAMIDVWKRTAALSVHPEQVTTTP-------------------LLNP-----SAPDSSELRS 788
            |.|...|   .|:|:.:: |.....||                   ..||     |..:|...:.
Frog   687 AQNSGTI---TRSASANI-PRGFVLTPNEFNSPPYYAFSPATHSHATSNPGDGPASTTNSISNQI 747

  Fly   789 LTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDV---FMTELENRTKK 850
            |.|::..|.||    .|.|..|.::|.:....:.::..    :.|:...||   .:...||..:.
Frog   748 LQASKPATPTT----LQLPPAPTLRHISKPEATHIIPM----TTKEDSCDVSSCLVASKENVPRA 804

  Fly   851 RVTLSLHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSII-----LIDEYEDFEEEDLNC 910
            :.:|..|      :.:::..     |....|.||...|..|.|..     ||...|:...: |:|
Frog   805 QTSLVRH------FVRRKSL-----EAESGLLSSNPFTHKDFSKSFSVQNLIQSTEELNAQ-LSC 857

  Fly   911 ------EGEMDHFPTWEIDSDIGVE-VDVDADADGDCDESTEDTALLQCATRTAIVITPISPVSS 968
                  .|..:.:|.|: :|.:.:| .::|.:......:||.:|:||..:.||.|       ..|
Frog   858 SDSSVSRGSQEMYPEWK-ESKLFIEDEELDTETFDAASQSTVETSLLSDSLRTGI-------SRS 914

  Fly   969 AHNLQQLNDQTTTLNKSNL 987
            :.::.:..|.|.||:..|:
Frog   915 SQSICKTRDGTETLSLPNV 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	129/204 (63%)
		Ion_trans_2	221..295	CDD:285168	47/73 (64%)
		KCNQ_channel	<619..719	CDD:281513	59/109 (54%)
kcnq5	XP_002937201.3	Ion_trans	125..356	CDD:395416	147/230 (64%)
kcnq5	XP_002937201.3	KCNQ_channel	464..651	CDD:397540	80/245 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1358
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1195
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47876
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060