DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and kcnf1b

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_005157014.1	Gene:	kcnf1b / 100334378	ZFINID:	ZDB-GENE-090312-39	Length:	484	Species:	Danio rerio

Alignment Length:	352	Identity:	84/352 - (23%)
Similarity:	148/352 - (42%)	Gaps:	64/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDN-----DIYAFYDIRGYKG----------------------KCRPGRPNSERIL---QPRMS 36
            |||:     ::|.|.::...:|                      .|:......|..|   ..::.
Zfish    80 DPDSFKCIVEVYYFGEVHMKRGICPICFIKEMEFWKIDLSYLDECCKSNLTEKEEELAEIADKVK 144

  Fly    37 LLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPR-GLHAIFYHVMVFLMVFTCLALSVFSTIKEYE 100
            |:...|..:....|..|:::.   ::..:|:|. .|.|....|:.||.:.....:....|:.:.:
Zfish   145 LILDDLECDPAVSRTERWQKF---VWKLMEKPESSLPARVIAVVSFLFILISSVVMCLGTLPDLQ 206

  Fly   101 -EDAV------YILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL 158
             ||:.      ..|..:|...:.|||:|:..||.||..:.|:     .|.|:.    :||.:.:|
Zfish   207 VEDSEGNRVEHPSLDAIETACIGWFTVEYVLRLASSPNKLRF-----ALSFMN----MIDFLAVL 262

  Fly   159 ASIVV-----LGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQEL----I 214
            ...||     ||......|....|::.||..:|.|:.::.|....   |.::.||.::..    :
Zfish   263 PFYVVLVLTCLGTAMMELVNVQQAVQALRIMRIARIFKLARHSSG---LQTLTYALKRSFKELGL 324

  Fly   215 TTMYIGFLGLIFASFLVYMWEKDVNDK-FSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCC 278
            ..||:| :|:...|.|.|..|:...:. |.:..|:.||.:||:.||||||:.|.|..|:..|:..
Zfish   325 LLMYMG-VGIFVFSALGYTMEQSHPETLFRSIPQSFWWAIITMTTVGYGDIYPKTTLGRCNAAIS 388

  Fly   279 ALLGISFFALPAGILGSGFALKVQQQQ 305
            .|.|:...|||...:.:.|.:...:|:
Zfish   389 FLCGVIAIALPIHPIINNFVIYYNKQK 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/221 (28%)
		Ion_trans_2	221..295	CDD:285168	26/74 (35%)
		KCNQ_channel	<619..719	CDD:281513
kcnf1b	XP_005157014.1	BTB	23..129	CDD:197585	7/48 (15%)
		BTB	23..124	CDD:295341	6/43 (14%)
		Ion_trans	220..415	CDD:278921	60/207 (29%)
		Ion_trans_2	331..398	CDD:285168	23/66 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910