Protein Alignment CG18011 and ZNF90

DIOPT Version :10

• Sequence 1: NP_610559.1
• Gene: CG18011 / 36068
• FlyBaseID: FBgn0033491
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_009069.1
• Gene: ZNF90 / 7643
• HGNCID: 13165
• Length: 601
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 151/587 - (25%)
• Similarity: 226/587 - (38%)
• Gaps: 118/587 - (20%)

  Fly   386 HAPVAEIPI------YGSCPECKL--TFSNIL--QYNKHSCAHV-IKK-----------KRGFRS 428
            |..:|:.|:      ...|||..|  :|..::  :|.|....:: :||           |||:..
Human    68 HEMIAKSPVMCFHFAQDLCPEQSLKDSFQKVIVTRYEKREYGNLELKKGCESVDEGKVHKRGYNG 132

  Fly   429 YCEMCSLEFPSWKRFNFHSQFHLEKHRPRACFVCDYATTNIDELFQHLNYSHEPVGT----LFCD 489
             ...|.....|                  ..|.|| ....:..:|.:.| .|:...|    ..|.
Human   133 -LNQCLTATQS------------------KVFQCD-TYVKVSHIFSNSN-RHKIRDTGKKPFKCI 176

  Fly   490 LCDRTFRDPSVFMEHNKSHANVSSTTYSCSECMANFESRGRLNGHMRAMHGSV-ISCELCSREFA 553
            .|.:.|...|....|.|.|  ....|..|.||...|.....|..|.|...|.. ..||.|.:|..
Human   177 ECGKAFNQSSTLATHKKIH--TGEITCKCEECGKAFNRSSHLTSHKRIHTGEKRYKCEDCGKELK 239

  Fly   554 TEATYNIHMKKHLIIEKDVHVCSTCGLLSDSRETLLAHVNSVKTA--------CFGSKIDVELL- 609
            ..:|...|.:.|...::  :.|..||.......||.|| ..:.|.        |..:.|...:|
Human   240 YSSTLTAHKRIHTGEKR--YKCEDCGKELKYSSTLTAH-KRIHTGEKPYKCDKCGRAFISSSILY 301

  Fly   610 --------RDAYVCEYCSSYFKEKDCLQAHRDSGVHK-DGVFLCQPCGKEFPHMKLYRHHLRNYQ 665
                    ...|.||.|...||....|..|:  .:|. :..:.|:.|||.|....:.|
Human   302 VHKISHTEEKPYKCEECGKAFKLSSILSTHK--RIHTGEKPYKCEECGKAFRRSLVLR------- 357

  Fly   666 QLRSDSTHRRLEICVY-YMCDQENCTESYVNWNSLYTHKRRTHESASKQAEKSSKSAQEWVCQFC 729
                  ||:|:..... |.||:  |.:::::.:.||.||       ...:||     :.:.|:.|
Human   358 ------THKRIHTGEKPYKCDK--CGKAFISSSLLYKHK-------ISHSEK-----KPYKCEEC 402

  Fly   730 LKECRSKMSLSVHVARSHNNDN-VTCPLCNSSYKSHDALAKH---HAYWHEPIECPECFKIVKNR 790
            .|..:...:|::|.. ||..:. ..|..|:..:|...||:.|   |: ..:|.:|.||.|..|..
Human   403 GKAFKRSSTLTIHKI-SHTEEKPYKCQECDKVFKRSSALSTHKIIHS-GEKPYKCEECGKAFKRS 465

  Fly   791 RNYDTHVNVVHSNKKRYSCSVCQKGFYHKSEMEAHQKLH-GQS-YSCEQCSFTTRNKKSLSVHVL 853
            .|..|| .:.|:.:|.|.|..|.|.|.:.|.:..|:.:| |:: |.||:|....:....||.|.:
Human   466 SNLTTH-KISHTEEKLYKCQECDKAFKYSSALSTHKIIHSGENPYKCEECGKAFKRSSVLSKHKI 529

  Fly   854 GQHYKRFAFECNVCKKRFGRSQGLKTHMQRAHGDK-YTCRDYFDGGCGRTFVNSSQLNVHVRKIH 917
             .|.....::|..|.|.|.||..|.:|.....|:| |.|.:     ||:.|..||.||.| ::||
Human   530 -IHTGAKPYKCEECGKAFKRSSQLTSHKISHTGEKPYKCEE-----CGKAFNLSSDLNTH-KRIH 587

  Fly   918 DG 919
            .|
Human   588 IG 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18011	NP_610559.1	C2H2 Zn finger	488..508	CDD:275368	6/19 (32%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..596	CDD:275371	7/20 (35%)
		C2H2 Zn finger	754..775	CDD:275368	7/23 (30%)
		C2H2 Zn finger	780..801	CDD:275368	8/20 (40%)
		C2H2 Zn finger	809..829	CDD:275368	6/19 (32%)
		SUF4-like	852..>891	CDD:411020	12/39 (31%)
		C2H2 Zn finger	864..885	CDD:411020	8/20 (40%)
		C2H2 Zn finger	864..885	CDD:275368	8/20 (40%)
		C2H2 Zn finger	891..917	CDD:275368	9/25 (36%)
ZNF90	NP_009069.1	KRAB	4..62	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368	6/19 (32%)
		COG5048	202..588	CDD:227381	117/427 (27%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	7/20 (35%)
		C2H2 Zn finger	287..307	CDD:275368	3/19 (16%)
		C2H2 Zn finger	315..335	CDD:275368	7/21 (33%)
		C2H2 Zn finger	343..363	CDD:275368	9/32 (28%)
		C2H2 Zn finger	371..391	CDD:275368	7/28 (25%)
		C2H2 Zn finger	399..419	CDD:275368	5/20 (25%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	8/20 (40%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	6/20 (30%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
		C2H2 Zn finger	567..587	CDD:275368	9/25 (36%)