Protein Alignment CG18011 and ZNF544

DIOPT Version :10

• Sequence 1: NP_610559.1
• Gene: CG18011 / 36068
• FlyBaseID: FBgn0033491
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001374339.1
• Gene: ZNF544 / 27300
• HGNCID: 16759
• Length: 769
• Species: Homo sapiens
• Alignment Length: 817
• Identity: 182/817 - (22%)
• Similarity: 285/817 - (34%)
• Gaps: 228/817 - (27%)

  Fly   170 VSKSEPKLVSKVADQEHFSVLIQNILDEEEAVVE------DETAVKEESSEAVQVTEE-TEAPGQ 227
            :|||:  ::|::..:|......|....:.:|.:|      ::...:||.|..|:|... .|.|..
Human   111 LSKSD--VISQLEQEEDLCRAEQEAPRDWKATLEENRLNSEKDRAREELSHHVEVYRSGPEEPPS 173

  Fly   228 IVILNSEAVTDTNPDENVYIYEHEDVMDPNLDNVKVKPISCSSRLVAQAEESQSDDDIDEGETSN 292
            :|:...:       |::..:.||::      ::::...:: |.||.||.|..:.:........|.
Human   174 LVLGKVQ-------DQSNQLREHQE------NSLRFMVLT-SERLFAQREHCELELGGGYSLPST 224

  Fly   293 VVLFNFVDIKEKDEVDNIPEYLATVVKTSFEKLTFQWCTV---------------CKHC-SLKCP 341
            :.|              :|..|.|  .|.|.|...|...:               .||| |.:|.
Human   225 LSL--------------LPTTLPT--STGFPKPNSQVKELKQNSAFINHEKNGADGKHCESHQCA 273

  Fly   342 T--FESLF-SHLSKAHKSRRDVYECPIEG---------CNKELKGRKF-------------LAMH 381
            .  .:|:: |.|......:::.||..:.|         |   ..||.|             |..|
Human   274 RAFCQSIYLSKLGNVETGKKNPYEYIVSGDSLNYGSSLC---FHGRTFSVKKSDDCKDYGNLFSH 335

  Fly   382 LVLLHAPVAEIPI-YG----SCPECKLTFSNILQYNKHSCAHVIKKKRG------FRSYCEMCSL 435
            .|.|:   .:.|: :|    .|.||:.|.|..|      |  :::.:|.      ||  ||....
Human   336 SVSLN---EQKPVHFGKSQYECDECRETCSESL------C--LVQTERSGPGETPFR--CEERCA 387

  Fly   436 EFPSWKRFNFHSQFHLEKHRPRACFVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRTFRDPSV 500
            .||....|: .........:|..|..|..:.:....:.|..:...:|   ..|..|.::|.....
Human   388 AFPMASSFS-DCNIIQTTEKPSVCNQCGKSFSCCKLIHQRTHTGEKP---FECTQCGKSFSQSYD 448

  Fly   501 FMEHNKSHANVSSTTYSCSECMANFESRGRLNGHMRAMHG-SVISCELCSREFATEATYNIHMKK 564
            .:.|.::|  .....|.|..|..:|..|.:|..|.|...| ....|..|.:.|        ....
Human   449 LVIHQRTH--TGEKPYECDLCGKSFTQRSKLITHQRIHTGEKPYQCIECRKSF--------RWNS 503

  Fly   565 HLIIEKDVHVCSTCGLLSDSRETLLAHVNSVKTACFGSKIDVELLRDAYVCEYCSSYFKEKDCLQ 629
            :||:.:.:|.                          |.|        .|.|.:|...|.:...|.
Human   504 NLIVHQRIHT--------------------------GEK--------PYECTHCGKSFSQSYELV 534

  Fly   630 AHRDSGVHK-DGVFLCQPCGKEFPHMKLYRHHLRNYQQLRSDSTHRRLEICVYYMCDQENCTESY 693
            .|:.:  |. :..|.|..|||.|.         :.|..:....||...:   .|.|:.  |.:|:
Human   535 THKRT--HTGEKPFKCTQCGKSFS---------QKYDLVVHQRTHTGEK---PYECNL--CGKSF 583

  Fly   694 VNWNSLYTHKR-RTHESASKQAEKSSKSAQEWVCQFCLKECRSKMSLSVHVARSHNNDN-VTCPL 756
            ...:.|.||:| .|.|             :.:.|..|.|..|...:|.:| .|.|..:. ..|..
Human   584 SQSSKLITHQRIHTGE-------------KPYQCIECGKSFRWNSNLVIH-QRIHTGEKPYDCTH 634

  Fly   757 CNSSYKSHDALAKH---HAYWHEPIECPECFKIVKNRRNYDTHVNVVHSNKKRYSCSVCQKGFYH 818
            |..|:.....|..|   |. ..:|.||.||.|..........|:. :|:.:|.|.|:.|.|.|..
Human   635 CGKSFSQSYQLVAHKRTHT-GEKPYECNECGKAFNRSTQLIRHLQ-IHTGEKPYKCNQCNKAFAR 697

  Fly   819 KSEMEAHQKLHGQSYSCEQCSFTTRNKKSLSVHVLGQHYKRFAFECNVCKKRFGRSQGLKTHMQR 883
            .|.:..||:.|            |..|               .|||:.|.|.|..|..|.:|.:.
Human   698 SSYLVMHQRTH------------TGEK---------------PFECSQCGKAFSGSSNLLSHHRI 735

  Fly   884 AHGDK-YTCRDYFDGGCGRTFVNSSQLNVHVRKIHDG 919
            ..|:| |.|.|     ||::|...|||.|| |:.|.|
Human   736 HSGEKPYECSD-----CGKSFRQQSQLVVH-RRTHTG 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18011	NP_610559.1	C2H2 Zn finger	488..508	CDD:275368	4/19 (21%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	3/19 (16%)
		C2H2 Zn finger	575..596	CDD:275371	0/20 (0%)
		C2H2 Zn finger	754..775	CDD:275368	6/23 (26%)
		C2H2 Zn finger	780..801	CDD:275368	5/20 (25%)
		C2H2 Zn finger	809..829	CDD:275368	7/19 (37%)
		SUF4-like	852..>891	CDD:411020	12/39 (31%)
		C2H2 Zn finger	864..885	CDD:411020	7/20 (35%)
		C2H2 Zn finger	864..885	CDD:275368	7/20 (35%)
		C2H2 Zn finger	891..917	CDD:275368	11/25 (44%)
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630	5/17 (29%)
		C2H2 Zn finger	410..428	CDD:275368	3/17 (18%)
		zf-H2C2_2	424..445	CDD:463886	5/23 (22%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		COG5048	460..>753	CDD:227381	94/398 (24%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	5/27 (19%)
		C2H2 Zn finger	520..540	CDD:275368	5/21 (24%)
		C2H2 Zn finger	548..568	CDD:275368	6/28 (21%)
		C2H2 Zn finger	576..596	CDD:275368	7/21 (33%)
		C2H2 Zn finger	604..624	CDD:275368	7/20 (35%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
		C2H2 Zn finger	660..680	CDD:275368	5/20 (25%)
		C2H2 Zn finger	688..708	CDD:275368	7/19 (37%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368	11/25 (44%)