Protein Alignment gem and Tfcp2l1

DIOPT Version :10

• Sequence 1: NP_610556.1
• Gene: gem / 36064
• FlyBaseID: FBgn0050011
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_076244.2
• Gene: Tfcp2l1 / 81879
• MGIID: 2444691
• Length: 479
• Species: Mus musculus
• Alignment Length: 581
• Identity: 204/581 - (35%)
• Similarity: 291/581 - (50%)
• Gaps: 160/581 - (27%)

  Fly   374 LSVLDPAKIEIGSANGATHAEDHKFQYILAAATSIATKNNEETLTYLNQGQSYEIKL---KKIGD 435
            |.:....:.::...|||...   ..||:|.||||.|.|.:|||||||||||||||:|   :|:||
Mouse    26 LPIFKQEEPQLSPENGARLP---PLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGD 87

  Fly   436 LSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQSRPGERIIEVDVPLSYGLCHVSQPLSSGSL 500
            ......|.:||:|::.||:||||:.|.:|::.|:.||||:||:::|:|||.|:  :....|...|
Mouse    88 FQDLNTKYVKSIIRVVFHDRRLQYTEYQQLEGWRWSRPGDRILDIDIPLSVGI--LDPRASPTQL 150

  Fly   501 NTVEIFWDPLKEVGVYIKVNCISTEFTPKKHGGEKGVPFRLQIETYIENTNSATASGSGGSNNSA 565
            |.||..|||.|....:|:|:||||||||:|||||||||||:||:|:.:|
Mouse   151 NAVEFLWDPSKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQN---------------- 199

  Fly   566 IASGSGSSGSAAPASPERTPSAGSNGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKRPQSEQE 630
             .||..|                    :.:|:|:|||||||.||||||.|.||||::||...|:|
Mouse   200 -ESGDYS--------------------EHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKE 243

  Fly   631 KFQPSYECTIMNDISLDLVMSATTTGCYSPEYMKLWPNSPVHIPKYDGMLPFAPSAASPATSSSP 695
            |:|||||.||:             |.| ||     ||:.|..          |.:..||:.:.||
Mouse   244 KYQPSYETTIL-------------TEC-SP-----WPDVPYQ----------ANNTPSPSYNGSP 279

  Fly   696 IAINS--VTSTNSPTLKLMDATNMVSPQHVPADMDDYSQNIMPESTPSQVTQWLTNHRLTAYLST 758
               ||  :...||            ||.|....:...|.:::|.::.....|||..:|.:.:...
Mouse   280 ---NSFGLREGNS------------SPNHPVEPLPLGSDHLLPSASIQDAQQWLHRNRFSQFCWL 329

  Fly   759 FAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYA-----------------SV 806
            ||.|||||:::||::||:|:||.|||||:||.::.:.:.|::|:|.                 |.
Mouse   330 FASFSGADLLKMSRDDLVQVCGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNQLPLPQKQDDSG 394

  Fly   807 DG--CSYNAIYLLSNTAKELQQKLFKMPGFYEFMAKASAQENGAGGAATAAAAALFNNWGMHSKY 869
            |.  |.|:||:|...|..||.:|:                                     .|.|
Mouse   395 DNSLCVYHAIFLEELTTLELTEKI-------------------------------------ASLY 422

  Fly   870 SGSGSNIFNDANKSCVYISGPSGILVTITDEVLNNEIKDGSLYALEVQAGK------VILK 924
            |....:|..      ||..||:||.|.:::|::.| .:|.|.:.|.....:      :|||
Mouse   423 SIPPQHIHR------VYRQGPAGIHVVVSNEMVQN-FQDESCFILSTLKAESNDGYHIILK 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..627	CDD:461338	111/236 (47%)
		SAM_CP2-like	739..805	CDD:188936	28/82 (34%)
Tfcp2l1	NP_076244.2	Mediate transcriptional repression	1..52		6/28 (21%)
		CP2	35..237	CDD:461338	112/243 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..248		18/28 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..301		15/65 (23%)
		SAM2-like domain. /evidence=ECO:0000250|UniProtKB:Q9NZI6	261..365		41/128 (32%)
		SAM_LBP9	310..376	CDD:188989	28/65 (43%)