DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gem and UBP1

DIOPT Version :9

Sequence 1:	NP_610556.1	Gene:	gem / 36064	FlyBaseID:	FBgn0050011	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001121633.1	Gene:	UBP1 / 7342	HGNCID:	12507	Length:	540	Species:	Homo sapiens

Alignment Length:	655	Identity:	218/655 - (33%)
Similarity:	334/655 - (50%)	Gaps:	157/655 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 IAKLDEVQNSPSQAISGQDSANGSGSAANGKHDVNSGLACGCGSPQGSPLANAEYELNEKGKPQQ 373
            :.|:|||..              ||..    ||.::.|: |.|...|:    ..|.:::
Human     4 VLKMDEVIE--------------SGLV----HDFDASLS-GIGQELGA----GAYSMSD------ 39

  Fly   374 LSVLDPAKIEIGSANGATHAEDHKFQYILAAATSIATKNNEETLTYLNQGQSYEIKL---KKIGD 435
            :..|...|.|..|.......|...|||::.||||.|.|.::||||||||||||||::   :|:||
Human    40 VLALPIFKQEDSSLPLDGETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGD 104

  Fly   436 LSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQSRPGERIIEVDVPLSYGLCHVSQPLSSGSL 500
            :.....|::||:|::.||:||||:.|.:|::.|:.:|||:|::::|:|:|.|:  :....:...|
Human   105 MPEINGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGI--IDTRTNPSQL 167

  Fly   501 NTVEIFWDPLKEVGVYIKVNCISTEFTPKKHGGEKGVPFRLQIETYIENTNSATASGSGGSNNSA 565
            |.||..|||.|....:|:|:||||||||:|||||||||||:|::|:.:|.|.
Human   168 NAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENG------------- 219

  Fly   566 IASGSGSSGSAAPASPERTPSAGSNGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKRPQSEQE 630
                            |.|        ..:|:|:|||||||.||||||.|.||||::||...|:|
Human   220 ----------------EYT--------DHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAHEKE 260

  Fly   631 KFQPSYECTIMNDISLDLVM----------------------SATTTGCYSPEYMKLWPNSPVHI 673
            |:||||:.||:.::.|:.::                      |....|..||     ||::|.
Human   261 KYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSP-----WPDAPT-- 318

  Fly   674 PKYDGMLPFAPSAASPATSSSPIAINSVTSTNSPTLKLMDATNMVSPQHVPADMDDYSQ----NI 734
                   .:..::.|||.        :.||....|..:.| :|..||.|   ..|..||    .|
Human   319 -------AYVNNSPSPAP--------TFTSPQQSTCSVPD-SNSSSPNH---QGDGASQTSGEQI 364

  Fly   735 MPESTPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPR 799
            .|.:|..:..|||..:|.::|...|:.|||||:::::||||:||||.|||||::|.|:::::.||
Human   365 QPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPR 429

  Fly   800 LTLYASVDGCSYNAIYLLSNTAKELQQKLFKMPGFYEFMAKASAQENGAGGAATAAAAALFNNWG 864
            ||:|.    |....    |:|..:.||:           |.:||.|||:|  |.....|::....
Human   430 LTIYV----CREQP----SSTVLQGQQQ-----------AASSASENGSG--APYVYHAIYLEEM 473

  Fly   865 MHSKYSGSGSNIFN----DANKSCVYISGPSGILVTITDEVLNNEIKDGSLYALEVQAGK----- 920
            :.|:.:...:.:||    ..|:  ||..||:||.:.::|:::.| .:|.|.:.......:
Human   474 IASEVARKLALVFNIPLHQINQ--VYRQGPTGIHILVSDQMVQN-FQDESCFLFSTVKAESSDGI 535

  Fly   921 -VILK 924
             :|||
Human   536 HIILK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..624	CDD:282385	103/233 (44%)
gem	NP_610556.1	SAM_CP2-like	739..805	CDD:188936	32/65 (49%)
UBP1	NP_001121633.1	CP2	54..254	CDD:282385	103/238 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..270		21/33 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..368		23/108 (21%)
		SAM_LBP1	369..435	CDD:188987	32/69 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144548
Domainoid	1	1.000	184	1.000	Domainoid score	I3414
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2511
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001863
OrthoInspector	1	1.000	-	-		otm40582
orthoMCL	1	0.900	-	-		OOG6_104886
Panther	1	1.100	-	-	LDO	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890