DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gem and GRHL3

DIOPT Version :9

Sequence 1:	NP_610556.1	Gene:	gem / 36064	FlyBaseID:	FBgn0050011	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_937817.3	Gene:	GRHL3 / 57822	HGNCID:	25839	Length:	626	Species:	Homo sapiens

Alignment Length:	562	Identity:	133/562 - (23%)
Similarity:	217/562 - (38%)	Gaps:	148/562 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 DQIKPSPKVSLDNASASPSIAIAKLDEVQNSPSQAISGQ-DS---------ANGSGSAANGKHDV 342
            |.:|.:..:||:.|..:|    .|...:...||:..:|. ||         .|||         :
Human   125 DLLKKNNLMSLEGALPTP----GKAAPLPAGPSKLEAGSVDSYLLPTTDMYDNGS---------L 176

  Fly   343 NSGLACGCGSPQGSPLANAEYELNEKGKPQQLSVLDPAKIEIGSANGATHAEDH-----KFQYIL 402
            ||......|.|   |....:.:...|..||: |:|.|..::  ::......||:     .|:|.|
Human   177 NSLFESIHGVP---PTQRWQPDSTFKDDPQE-SMLFPDILK--TSPEPPCPEDYPSLKSDFEYTL 235

  Fly   403 AAATSIATKNNEETLTYLNQGQSYEIKLKKIG---DLSLYRDKILKSVIKICFHERRLQFMEREQ 464
            .:..:|..|:.|..:.|||:||.|.:.|:...   .|:|..:|: |||:.:.|...::...:...
Human   236 GSPKAIHIKSGESPMAYLNKGQFYPVTLRTPAGGKGLALSSNKV-KSVVMVVFDNEKVPVEQLRF 299

  Fly   465 MQQWQQSRP--GERIIEV-DVPLSYGLC-HVSQPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTE 525
            .:.|...:|  .:|:|:| |...::... |:.:.    :.|.:...|:..:|..|:|.|||:||:
Human   300 WKHWHSRQPTAKQRVIDVADCKENFNTVEHIEEV----AYNALSFVWNVNEEAKVFIGVNCLSTD 360

  Fly   526 FTPKKHGGEKGVPFRLQIETYIENTNSATASGSGGSNNSAIASGSGSSGSAAPASPERTPSAGSN 590
            |:.:|  |.||||..|||:||                                       ..|..
Human   361 FSSQK--GVKGVPLNLQIDTY---------------------------------------DCGLG 384

  Fly   591 GKQAVHAAACQIKVFKLKGADRKHKQDREKIQKRPQSEQEKFQPSYECTIMNDISLDLVMSATTT 655
            .::.||.|.||||:|..|||:||.:.|          |:::|:...:|.   |.|...|.....:
Human   385 TERLVHRAVCQIKIFCDKGAERKMRDD----------ERKQFRRKVKCP---DSSNSGVKGCLLS 436

  Fly   656 GCYSPEYMKLWPNSPVHIPKYDGMLPFAPS--------AASPATSSSPIAINSVTSTNSPTLKLM 712
            |....|...|.|.:.:..|.    :.|.|:        :...|.|:.|      :|:|...||
Human   437 GFRGNETTYLRPETDLETPP----VLFIPNVHFSSLQRSGGAAPSAGP------SSSNRLPLK-- 489

  Fly   713 DATNMVSPQHVPADMDDYSQNIMPESTPSQVTQWLTNHRLTAYL--STFAQFSGADIMRMSKEDL 775
               ...||         :::...|  .||:..:.....|:..|:  .|...|   |.:.:...||
Human   490 ---RTCSP---------FTEEFEP--LPSKQAKEGDLQRVLLYVRRETEEVF---DALMLKTPDL 537

  Fly   776 IQICGLADGIRMFNILRAKTIAPRLTLYASVDGCSYNAIYLL 817
                   .|:|  |.:..|...|...:|.....|......||
Human   538 -------KGLR--NAISEKYGFPEENIYKVYKKCKRGETSLL 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..624	CDD:282385	66/242 (27%)
gem	NP_610556.1	SAM_CP2-like	739..805	CDD:188936	15/67 (22%)
GRHL3	NP_937817.3	Transcription activation. /evidence=ECO:0000269\|PubMed:12549979	30..95
GRHL3	NP_937817.3	CP2	210..421	CDD:282385	68/268 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144552
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840