DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gem and tfcp2

DIOPT Version :9

Sequence 1:	NP_610556.1	Gene:	gem / 36064	FlyBaseID:	FBgn0050011	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_012812136.1	Gene:	tfcp2 / 403094	XenbaseID:	XB-GENE-485720	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	567	Identity:	209/567 - (36%)
Similarity:	293/567 - (51%)	Gaps:	157/567 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 FQYILAAATSIATKNNEETLTYLNQGQSYEIKL---KKIGDLSLYRDKILKSVIKICFHERRLQF 459
            |||:|..|||.|.|.:|||||||||||||||::   :|:|:|.....|::||:.::.||:||||:
Frog    67 FQYVLCTATSPAVKLHEETLTYLNQGQSYEIRMLDNRKMGELPELNGKLVKSIFRVVFHDRRLQY 131

  Fly   460 MEREQMQQWQQSRPGERIIEVDVPLSYGLCHVSQPLSSGSLNTVEIFWDPLKEVGVYIKVNCIST 524
            .|.:|::.|:.:|||:||:::|:|:|.|:  :....:...|||||..|||.|...|:|:|:||||
Frog   132 TEHQQLEGWRWNRPGDRILDIDIPMSVGI--IDPRANPTQLNTVEFLWDPAKRTSVFIQVHCIST 194

  Fly   525 EFTPKKHGGEKGVPFRLQIETYIENTNSATASGSGGSNNSAIASGSGSSGSAAPASPERTPSAGS 589
            |||.:|||||||||||:||:|:.||.|.                             |.|
Frog   195 EFTMRKHGGEKGVPFRVQIDTFKENENG-----------------------------EYT----- 225

  Fly   590 NGKQAVHAAACQIKVFKLKGADRKHKQDREKIQKRPQSEQEKFQPSYECTIMNDISLDLVMSATT 654
               :.:|:|:|||||||.||||||.|.||||::||...|:||:|||||.||:
Frog   226 ---EHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPQEKEKYQPSYETTIL------------- 274

  Fly   655 TGCYSPEYMKLWPNSPVHIPKYDGMLPFAPSAASPATSSSPIAINSVTSTNSPTLKLMDATNMVS 719
            |.| ||     ||.           :.:..:|.||..:||.   ||.......|..|..|.| .|
Frog   275 TEC-SP-----WPE-----------ITYVSNAPSPGFNSSH---NSFPIGEGQTKPLETARN-GS 318

  Fly   720 PQH---VPADMDDYS------QNIMPESTPSQVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDL 775
            |.|   .||.:.|.|      ||::|.|||.:..|||..:|..|:...|..|||||:::::::|:
Frog   319 PNHQPEPPAPIVDVSAGLTPIQNLLPTSTPQEAQQWLHRNRFAAFSRLFTNFSGADLLKLTRDDV 383

  Fly   776 IQICGLADGIRMFNILRAKTIAPRLTLYASVD------------------GCS----YNAIYLLS 818
            |||||.|||||:||.|:.:.:.||||:|...:                  |.|    |:||||..
Frog   384 IQICGPADGIRLFNALKGRMVRPRLTIYVCQESQQLREQQQQHKHENGEAGNSAFYVYHAIYLEE 448

  Fly   819 NTAKELQQKLFKMPGFYEFMAKASAQENGAGGAATAAAAALFNNWGMHSKYSGSGSNIFNDANKS 883
            .||.||.:|:                            |.||:               .:....:
Frog   449 MTAIELTEKI----------------------------AQLFS---------------ISPHQIN 470

  Fly   884 CVYISGPSGILVTITDEVLNNEIKDGSLYALEVQAGK------VILK 924
            .:|..||:||.|.|:||::.| .:|.|.:.|:....:      :|||
Frog   471 QIYKQGPTGIHVLISDEMIQN-FQDESCFILDTMKAETNDSYHIILK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..624	CDD:282385	106/228 (46%)
gem	NP_610556.1	SAM_CP2-like	739..805	CDD:188936	32/65 (49%)
tfcp2	XP_012812136.1	CP2	52..257	CDD:367976	106/228 (46%)
tfcp2	XP_012812136.1	SAM_TFCP2	347..413	CDD:188988	32/65 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3395
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4134
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2554
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001863
OrthoInspector	1	1.000	-	-		otm47757
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4859
SonicParanoid	1	1.000	-	-		X1220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.090