DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gem and Tfcp2

DIOPT Version :9

Sequence 1:	NP_610556.1	Gene:	gem / 36064	FlyBaseID:	FBgn0050011	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_006242403.1	Gene:	Tfcp2 / 315309	RGDID:	1306738	Length:	501	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	207/604 - (34%)
Similarity:	300/604 - (49%)	Gaps:	166/604 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 GSPLANAEYELNEKGKPQQLSVLDPAKIEIGSANGATHAEDHKFQYILAAATSIATKNNEETLTY 419
            |..|....|.:::      :..|...|.|..|.......|...|||:|.||||.|.|.::|||||
  Rat    30 GQELGAGAYSMSD------VLALPIFKQEESSLPPENENEILPFQYVLCAATSPAVKLHDETLTY 88

  Fly   420 LNQGQSYEIKL---KKIGDLSLYRDKILKSVIKICFHERRLQFMEREQMQQWQQSRPGERIIEVD 481
            |||||||||::   :|:|:|.....|::||:.::.||:||||:.|.:|::.|:.:|||:||:::|
  Rat    89 LNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDID 153

  Fly   482 VPLSYGLCHVSQPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTEFTPKKHGGEKGVPFRLQIETY 546
            :|:|.|:  :....:...|||||..|||.|...|:|:|:|||||||.:|||||||||||:||:|:
  Rat   154 IPMSVGV--IDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTF 216

  Fly   547 IENTNSATASGSGGSNNSAIASGSGSSGSAAPASPERTPSAGSNGKQAVHAAACQIKVFKLKGAD 611
            .||.|.                             |.|        :.:|:|:|||||||.||||
  Rat   217 KENENG-----------------------------EYT--------EHLHSASCQIKVFKPKGAD 244

  Fly   612 RKHKQDREKIQKRPQSEQEKFQPSYECTIMNDISLDLVMSATTTGCYSPEYMKLWPNSPVHIPKY 676
            ||.|.||||::||...|:||:|||||.||:             |.| ||     ||.
  Rat   245 RKQKIDREKMEKRTPHEKEKYQPSYETTIL-------------TEC-SP-----WPE-------- 282

  Fly   677 DGMLPFAPSAASPATSSSPIAINSVTSTNSPTLKLMDATNMVSPQHVPADMDDYSQNIMPESTPS 741
               :.:..::.||..:||..:. |:...|.            ||.|.|......:.|::|.:||.
  Rat   283 ---ITYVSNSPSPGFNSSHSSF-SLGEGNG------------SPNHQPEPPPPVTDNLLPTTTPQ 331

  Fly   742 QVTQWLTNHRLTAYLSTFAQFSGADIMRMSKEDLIQICGLADGIRMFNILRAKTIAPRLTLYA-- 804
            :..|||..:|.:.:...|..|||||:::::::|:|||||.|||||:||.|:.:.:.||||:|.
  Rat   332 EAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQ 396

  Fly   805 -----------------SVDGCS------YNAIYLLSNTAKELQQKLFKMPGFYEFMAKASAQEN 846
                             ..||.|      |:||||...||.||.:|:
  Rat   397 ESLQLREQPQQPQPQQKQEDGDSNGTFFVYHAIYLEELTAVELTEKI------------------ 443

  Fly   847 GAGGAATAAAAALFNNWGMHSKYSGSGSNIFNDANKSCVYISGPSGILVTITDEVLNNEIKDGSL 911
                      |.||:               .:....|.:|..||:||.|.|:||::.| .::.:.
  Rat   444 ----------AQLFS---------------ISPQQISQIYKQGPTGIHVLISDEMVQN-FQEEAC 482

  Fly   912 YALEVQAGK------VILK 924
            :.|:....:      ||||
  Rat   483 FILDTMEAETSDSYHVILK 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..624	CDD:282385	107/233 (46%)
gem	NP_610556.1	SAM_CP2-like	739..805	CDD:188936	31/84 (37%)
Tfcp2	XP_006242403.1	CP2	52..259	CDD:398291	111/245 (45%)
Tfcp2	XP_006242403.1	SAM_TFCP2	329..395	CDD:188988	31/65 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338251
Domainoid	1	1.000	183	1.000	Domainoid score	I3339
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4134
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2457
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001863
OrthoInspector	1	1.000	-	-		otm44722
orthoMCL	1	0.900	-	-		OOG6_104886
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1220
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890