DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gem and Grhl1

DIOPT Version :9

Sequence 1:	NP_610556.1	Gene:	gem / 36064	FlyBaseID:	FBgn0050011	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001154878.1	Gene:	Grhl1 / 195733	MGIID:	2182540	Length:	618	Species:	Mus musculus

Alignment Length:	511	Identity:	121/511 - (23%)
Similarity:	201/511 - (39%)	Gaps:	144/511 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 WDSLDIGQSENSPTA------SQSGDLPS-----------KVAHQEKE-------KHKREKHSGR 245
            |.|.    .||..||      |.:||..|           ||..:.:.       :|...:||.|
Mouse    33 WKSF----LENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSAVKPEGEHPEPEHSKR 93

  Fly   246 SSWSDDIGFDL-NAEFNSNSYLNNENFLSFSPTLTTLKQEPQTDQIKPSPKVSLDNASASPSIAI 309
            :|..:.....| :|..|....|.|   :.|:..|      |.::|:....:..|.....:.:::|
Mouse    94 NSIPNVTEQPLISAGENRVQVLKN---VPFNIVL------PHSNQLGIDKRGHLTAPDTTVTVSI 149

  Fly   310 AKL------DEVQ--------------NSPSQAISGQDSANGSGSAANGKHDVNSGLACGCGSPQ 354
            |.:      .|:|              :.|::.:...|.:..:...::|....|:...    :|.
Mouse   150 ATMPTHSIKTEIQPHGFAVGIPPAVYHSEPTERVVVFDRSLSTDQFSSGTQPPNAQRR----TPD 210

  Fly   355 GSPLANAEYELNEKGKPQQLSVLDPAKIEIGSANGATHAEDH--------KFQYILAAATSIATK 411
            .:.....:..:.|...|.:||:..|          ..::||:        .|:|.|.|:.|:..|
Mouse   211 STFSETFKEGVQEVFFPSELSLRMP----------GMNSEDYVFDNVSGNNFEYTLEASKSLRQK 265

  Fly   412 NNEETLTYLNQGQSYEIKLKKIGDLSLYRDKI--LKSVIKICFHERRLQFMEREQMQQW-----Q 469
            ..:.|:||||:||.|.:.||:..........|  ::|||.:.|.|.:   ...:|::.|     :
Mouse   266 QGDSTMTYLNKGQFYPVTLKEGSSNEGIHHPISKVRSVIMVVFAEDK---SREDQLRHWKYWHSR 327

  Fly   470 QSRPGERIIEV-DVPLSYGLCHVSQPLSSGSLNTVEIFWDPLKEVGVYIKVNCISTEFTPKKHGG 533
            |....:|.|:: |...|:   :....:...:.|.:...||...|..|:|.|||:||:|:.:|  |
Mouse   328 QHTAKQRCIDIADYKESF---NTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQK--G 387

  Fly   534 EKGVPFRLQIETYIENTNSATASGSGGSNNSAIASGSGSSGSAAPASPERTPSAGSNGKQAVHAA 598
            .||:|..:||:||..|..|                                       .:.||.|
Mouse   388 VKGLPLNIQIDTYSYNNRS---------------------------------------NKPVHRA 413

  Fly   599 ACQIKVFKLKGADRKHKQDREKIQKRPQSE-QEKFQPSYECTIMNDIS-----LDL 648
            .||||||..|||:||.:.:..|..||..|: :.:..||::.|   ||:     |||
Mouse   414 YCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVQLLPSHKRT---DITVFKPFLDL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gem	NP_610556.1	CP2	393..624	CDD:282385	69/246 (28%)
gem	NP_610556.1	SAM_CP2-like	739..805	CDD:188936
Grhl1	NP_001154878.1	Transcription activation. /evidence=ECO:0000250\|UniProtKB:Q8K5C0	1..91		13/61 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..100		5/23 (22%)
		CP2	235..440	CDD:282385	71/261 (27%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q9NZI5	380..389		4/10 (40%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q9NZI5	427..430		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840