Protein Alignment Pfk and PFK1

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_011756.1
• Gene: PFK1 / 853155
• SGDID: S000003472
• Length: 987
• Species: Saccharomyces cerevisiae
• Alignment Length: 847
• Identity: 343/847 - (40%)
• Similarity: 484/847 - (57%)
• Gaps: 71/847 - (8%)

  Fly   121 NNL-HNGFLNAVNY--SEKNAVKKKKSAPK---RKCGKSVDELRKCLRTMQDVIDFVHPVKPFKD 179
            ||: .:|..||.:.  :.|:|..:..|..:   |....:.|.||:.|.:.|            |.
Yeast   153 NNITFSGLANATDSAPTSKDAFLEATSEDEIISRASSDASDLLRQTLGSSQ------------KK 205

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.||||||.||||||||.||..|:.||.|:.:.|||:|::.||..:::..|..|...:..|
Yeast   206 KKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEG 270

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            ||:||:||..:||:|:||.:||.|||.:||..|||.|||||||||:|||.||.||:||||.....
Yeast   271 GTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRF 335

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |.|:...:..|.|||||||||||..|||.|||..:||.||.|.:|.|.:||.||.|.|::|||||
Yeast   336 TKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGR 400

  Fly   375 HCGYLALVGGLACEADFIFIPEMP-PKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPI 438
            |||:|||:.|:|..||:|||||.. |...|.|.|.....:.||.|:|.|.:||||||:|.:.:|:
Yeast   401 HCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPV 465

  Fly   439 TAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLD 503
            ||.|||..:.| |..|.::|:||||||||...|.||.||...|.:|..|::|.|.::...:|.:.
Yeast   466 TANDVKDALIE-LGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGIL 529

  Fly   504 GNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENF-----D 563
            .|:.:|:||:|.|:.|::||.|:..|.:..|:.||...|   :|.|          |||     .
Yeast   530 ENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEF---IELY----------ENFLSTTVK 581

  Fly   564 ADGKGI----EGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLI-AGNVRELG 623
            .||..:    :...:.::|:|||:..:|||.|:.....:..|...|.|.:|..||| .|.|:||.
Yeast   582 DDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELS 646

  Fly   624 WSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQ 688
            |.||..|...||:.:||.|::.......||...::.|:.||:|:||||.:.:..|:.|.|..:|.
Yeast   647 WIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPI 711

  Fly   689 FCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLAT 753
            |.||:.:||:|:||||||||:|||.||.||.:....|.|:|||..|:|||||.|..||:.||:|:
Yeast   712 FNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIAS 776

  Fly   754 LAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMA--EGVSRG--LILRNEKASENYSTDFIYRL 814
            ..||..||.:.|..|:|..:..:::|:..:.....  :|.:|.  |::|||:||..|||..:..:
Yeast   777 FTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADI 841

  Fly   815 YSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWL--------------AAQIKAN 865
            .||..||.|..|..|.||:||||.|:..||...::.|.||:.::              |..::..
Yeast   842 ISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFK 906

  Fly   866 IDANGVVNCKSP------DTATLLGIVSRQYRFSPLVDLIA-ETNFDQRIPKKQWWLRLRPLLRI 923
            .|.:|.   |.|      |:|.::.:......|.|:.:|.. |||.:.|...:..|.....:..|
Yeast   907 FDTHGE---KVPTVEHEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDI 968

  Fly   924 LA 925
            |:
Yeast   969 LS 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	328/782 (42%)
PFK1	NP_011756.1	Pfk_N	8..101	CDD:408261
		6PF1K_euk	206..972	CDD:274152	328/782 (42%)