Protein Alignment Pfk and Pfkm

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_038935791.1
• Gene: Pfkm / 65152
• RGDID: 68419
• Length: 851
• Species: Rattus norvegicus
• Alignment Length: 750
• Identity: 459/750 - (61%)
• Similarity: 589/750 - (78%)
• Gaps: 10/750 - (1%)

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.|||||:|||||||||.||:.|:.|.:|:|:.|||||:||||:.|:||.|.|||.::..|
  Rat    87 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLG 151

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            ||:||||||:|||||:|||:||:||::||||||.|||||||||||:.||.|||.||::|.|:..|
  Rat   152 GTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKI 216

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |.|:..|.:.|:||||||||||||||||||||||:|||||:|.:|||::||.||||||::|||||
  Rat   217 TAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGR 281

  Fly   375 HCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPIT 439
            ||||||||..|:|.||::||||.||..||.:.||.:|::.|:.|.||||:||||||:|:.|.|||
  Rat   282 HCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPIT 346

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :||:|.::.:||.:|.|:||||||||||.||||||||..|||.||.:||:|.|.|:...|:||.|
  Rat   347 SEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSG 411

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGI 569
            |||||:||||||:.|:.|.|||.|||:.:|:|||||||..|.|.||:|..::||.      .||
  Rat   412 NQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPV------SKG- 469

  Fly   570 EG-YRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQ 633
             | :.:|||::||||.||||||||.||..:.:|:.|..::||.|||..|.:.|.|||.|.||.||
  Rat   470 -GLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQ 533

  Fly   634 GGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPS 698
            ||:.||||||||:...::|:|.:.::.||||:||||||:|....::.:.|..:.:.|||.||||:
  Rat   534 GGSKLGTKRTLPKKNLEQISANITKYNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPA 598

  Fly   699 TISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADA 763
            |:||||||::||:|.||.||.|...||||:|||.|||||||:|||||||||||||:||||.||||
  Rat   599 TVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADA 663

  Fly   764 AYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMN 828
            |||:||.|:|:|||.:|.|:..||...|.|||:|||||.:|||:||||:.||||||||:|..|.|
  Rat   664 AYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKN 728

  Fly   829 ILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFS 893
            :||||||||||||||||..|||.||.::|::.:||.:. .||.:...:||:..:||:..|...|.
  Rat   729 VLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESY-RNGRIFANTPDSGCVLGMRKRALVFQ 792

  Fly   894 PLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHD 928
            |:.:|..:|:|:.||||:||||:|||:|:||||::
  Rat   793 PVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	459/749 (61%)
Pfkm	XP_038935791.1	Eukaryotic_PFK	84..845	CDD:238389	459/749 (61%)