DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfkla

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_698635.3	Gene:	pfkla / 570106	ZFINID:	ZDB-GENE-121207-1	Length:	780	Species:	Danio rerio

Alignment Length:	764	Identity:	428/764 - (56%)
Similarity:	562/764 - (73%)	Gaps:	12/764 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            :.:|..|||||:||||||:||..||.||:|.|||.:.|||||:|||||.|:.|||.||::||..|
Zfish    16 RAIAALTSGGDAQGMNAAIRAVTRMGIYVGAKVYLVYEGYQGLVDGGDNIKLANWQSVTNIIQLG 80

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            ||:||||||:.|..|:|||.||.||::|||:||.|.||||||||||:||.|||.||:|||:...|
Zfish    81 GTVIGSARCKAFTMREGRLAAAFNLVKRGISNLCVCGGDGSLTGANIFRAEWSGLLEELVQKGRI 145

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |.|..:|...|:||||||||||||||||||||.|:||:||.|.||||::||.||||||::|||||
Zfish   146 TAETAQKHGHLNIVGLVGSIDNDFCGTDMTIGADSALNRITEIIDAITTTATSHQRTFVLEVMGR 210

  Fly   375 HCGYLSVVAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPIT 439
            |||||::|:.:.|.||::|:||:||:..|.:.:..:||:.||.|.||||:|:||||:.|.|..||
Zfish   211 HCGYLALVSALASGADWLFIPEAPPEDGWEELMCARLEESRSKGCRLNIIIIAEGAISRSGEAIT 275

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :..:|.::..||.:|.|:||||||||||.||||||:|:.::|.||.:||:|||.|:...||.|.|
Zfish   276 SNYIKDLVVSRLGYDTRVTVLGHVQRGGTPSAFDRVLSSKLGVEAVVALLEATPDTPACVIGLSG 340

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGI 569
            |||||:||:|.||.|:.|.:||.|||:.:|::|||||||.|...||:|...|......:
Zfish   341 NQAVRLPLVEAVEMTKEVQRAMNEKRFEEAIQLRGRSFENNWSIYKLLAYQKSAAVQSE------ 399

  Fly   570 EGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQG 634
              :.:|::::||||.||||||||.||.|:..|..||.:|||.|||..|.|.|:.|:.|:||.|.|
Zfish   400 --HSIAILNVGAPAAGMNAAVRSAVRVALASGHRVYIVNDGFEGLAKGAVNEVSWNQVAGWTGLG 462

  Fly   635 GAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPST 699
            |:.||||||||.....::...|.:|.|..||:|||||:|....::.:.|..|.:.|||:.:||:|
Zfish   463 GSLLGTKRTLPSTCMDKLVENLNKFSIHSLLVIGGFEAYEGVLELVEARGRYDELCIPMCIIPAT 527

  Fly   700 ISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAA 764
            |||||||||||||.||.:|.....||:|:|||.||||||||:||||||||||||...:|.|||||
Zfish   528 ISNNVPGTEFSLGSDTAVNAAMSSCDKIKQSASGTKRRVFVVETMGGYCGYLATTTSIAVGADAA 592

  Fly   765 YIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNI 829
            ||:|:.|:|.||..:|.|:..||.:.:.|||:|||||..|:|:||||::|||.||||:|.||:||
Zfish   593 YIFEDPFNIHDLTTNVVHLTEKMKKDIQRGLVLRNEKCHEHYTTDFIHKLYSAEGKGVFDCRVNI 657

  Fly   830 LGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSP 894
            |||:||||.|||||||.|||:..:.|.||..::..:. ..|.|...:||||.::|:..:...|||
Zfish   658 LGHLQQGGVPTPFDRNYGTKLGVRAVQWLTEKMNDSF-RQGRVFANTPDTACVVGLYKKAMTFSP 721

  Fly   895 LVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEE 943
            :.:|..:|:|:.|:||.||||.||.:|::|||:.:::.|   |:|.|.|
Zfish   722 VTELKEQTDFEHRMPKTQWWLNLRLMLKMLAKYQTSFNE---YVTGEIE 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	414/733 (56%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	423/748 (57%)
pfkla	XP_698635.3	Eukaryotic_PFK	13..773	CDD:238389	428/764 (56%)
pfkla	XP_698635.3	6PF1K_euk	16..754	CDD:274152	422/746 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582065
Domainoid	1	1.000	443	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E1_COG0205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	955	1.000	Inparanoid score	I320
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D98300at33208
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm24665
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	O	PTHR13697
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2168
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800