Protein Alignment Pfk and pfkmb

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001352265.1
• Gene: pfkmb / 568001
• ZFINID: ZDB-GENE-081114-1
• Length: 899
• Species: Danio rerio
• Alignment Length: 760
• Identity: 449/760 - (59%)
• Similarity: 567/760 - (74%)
• Gaps: 16/760 - (2%)

  Fly   173 PVKPFK---DKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANW 234
            ||.|.|   .:.:||.|||||:|||||||||.||:.||.|.||||:.|||||:|||||.|::|.|
Zfish   129 PVDPTKMGVGRAIAVLTSGGDAQGMNAAVRATVRVGIYTGAKVYFVHEGYQGLVDGGDNIRQATW 193

  Fly   235 ASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSL 299
            .|||.::..|||:||||||||||.::||.|||.||::.|||||.||||||||||||.||.|||.|
Zfish   194 ESVSMMLQLGGTVIGSARCQDFRTKEGRAKAACNLVKLGITNLCVIGGDGSLTGANEFRNEWSEL 258

  Fly   300 LDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQ 364
            |..|.|...||.|:.:..:.|:|||:||||||||||||||||||:|||||:|.:|||::||.|||
Zfish   259 LQILQKTGKITAEEAKCSSHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIMEVVDAITTTAQSHQ 323

  Fly   365 RTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEG 429
            |.||:|||||||||||||..|:|.||::|||||||...|.|.||.:|..:||.|.|||::|||||
Zfish   324 RAFILEVMGRHCGYLALVTALSCGADWVFIPEMPPDEGWEDHLCRRLTYQRSIGNRLNVIIVAEG 388

  Fly   430 AMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKD 494
            |:||.|.|||.:.:|.::.::|..|.|.|:||||||||.||||||||..|||.||.:||:|||.|
Zfish   389 ALDRHGKPITCDIIKNLVTKKLGFDTRATILGHVQRGGTPSAFDRILGSRMGVEAVMALLEATPD 453

  Fly   495 SVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPP- 558
            :...|:||.||.|||:||||||:.|:.|.|||||.|:.:|:||||:|||.|..|||:|..:..|
Zfish   454 TPACVVSLSGNMAVRLPLMECVQVTKEVTKAMAEGRFEEAIKLRGKSFENNWNTYKLLAHVTAPD 518

  Fly   559 -KENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVREL 622
             |.|.:          :|::::|||..||||||||.||..|.:|..:..::||.|||..|.:..:
Zfish   519 VKSNIN----------IAILNVGAPCAGMNAAVRSAVRIGILQGHNMLAVHDGFEGLANGTIEPM 573

  Fly   623 GWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYP 687
            .|..|.||.|:||:.|||||:||....:||:..:.:|.|..|:||||||::....::...|:.|.
Zfish   574 AWGYVGGWTGKGGSILGTKRSLPANMIEEISLNIAKFNIHALVIIGGFEAFVGGLELVTAREKYE 638

  Fly   688 QFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLA 752
            :.|||:||||:|:||||||::||:|.||.||.||..||||:|||.|||||||:||||||||||||
Zfish   639 ELCIPLVVIPATVSNNVPGSDFSVGADTALNTITTTCDRIKQSAAGTKRRVFIIETMGGYCGYLA 703

  Fly   753 TLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSE 817
            |:||||.||||||::|:.|.|.||:.:|.|:..||...|.|||||||||.:.||:|||::.||||
Zfish   704 TMAGLAAGADAAYVFEDPFGIHDLEANVEHLLEKMKTTVKRGLILRNEKCNANYTTDFLFNLYSE 768

  Fly   818 EGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATL 882
            ||||:|.||.|:||||||||:|||||||.||||.||.|.||..::| ....:|.:...:||:|.:
Zfish   769 EGKGVFDCRKNVLGHMQQGGTPTPFDRNFGTKMGAKAVLWLTDKLK-ECYRHGRIFANTPDSACV 832

  Fly   883 LGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKH 927
            ||:..|...|.||.||..:|:|:.||||.:|||:|||:|:||||:
Zfish   833 LGMRKRAMLFQPLSDLKEDTDFEHRIPKTEWWLKLRPILKILAKY 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	445/750 (59%)
pfkmb	NP_001352265.1	Eukaryotic_PFK	136..896	CDD:238389	445/753 (59%)