DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfkmb

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001352265.1	Gene:	pfkmb / 568001	ZFINID:	ZDB-GENE-081114-1	Length:	899	Species:	Danio rerio

Alignment Length:	760	Identity:	443/760 - (58%)
Similarity:	563/760 - (74%)	Gaps:	16/760 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 PVKPFK---DKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANW 234
            ||.|.|   .:.:||.|||||:|||||||||.||:.||.|.||||:.|||||:|||||.|::|.|
Zfish   129 PVDPTKMGVGRAIAVLTSGGDAQGMNAAVRATVRVGIYTGAKVYFVHEGYQGLVDGGDNIRQATW 193

  Fly   235 ASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSL 299
            .|||.::..|||:||||||||||.::||.|||.||::.|||||.||||||||||||.||.|||.|
Zfish   194 ESVSMMLQLGGTVIGSARCQDFRTKEGRAKAACNLVKLGITNLCVIGGDGSLTGANEFRNEWSEL 258

  Fly   300 LDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQ 364
            |..|.|...||.|:.:..:.|:|||:||||||||||||||||||:|||||:|.:|||::||.|||
Zfish   259 LQILQKTGKITAEEAKCSSHLNIVGMVGSIDNDFCGTDMTIGTDSALHRIMEVVDAITTTAQSHQ 323

  Fly   365 RTFIMEVMGRHCGYLSVVAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEG 429
            |.||:||||||||||::|..:...||:||:||.||...|.|.|..:|..:||.|.|||::|||||
Zfish   324 RAFILEVMGRHCGYLALVTALSCGADWVFIPEMPPDEGWEDHLCRRLTYQRSIGNRLNVIIVAEG 388

  Fly   430 AMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKD 494
            |:||.|.|||.:.:|.::.::|..|.|.|:||||||||.||||||||..|||.||.:||:|||.|
Zfish   389 ALDRHGKPITCDIIKNLVTKKLGFDTRATILGHVQRGGTPSAFDRILGSRMGVEAVMALLEATPD 453

  Fly   495 SVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPP- 558
            :...|:||.||.|||:||||||:.|:.|.|||||.|:.:|:||||:|||.|..|||:|..:..|
Zfish   454 TPACVVSLSGNMAVRLPLMECVQVTKEVTKAMAEGRFEEAIKLRGKSFENNWNTYKLLAHVTAPD 518

  Fly   559 -KENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVREL 622
             |.|.:          :|::::|||..||||||||.||..|.:|..:..::||.|||..|.:..:
Zfish   519 VKSNIN----------IAILNVGAPCAGMNAAVRSAVRIGILQGHNMLAVHDGFEGLANGTIEPM 573

  Fly   623 GWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYP 687
            .|..|.||.|:||:.|||||:||....:||:..:.:|.|..|:||||||::....::...|:.|.
Zfish   574 AWGYVGGWTGKGGSILGTKRSLPANMIEEISLNIAKFNIHALVIIGGFEAFVGGLELVTAREKYE 638

  Fly   688 QFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLA 752
            :.|||:||||:|:||||||::||:|.||.||.||..||||:|||.|||||||:||||||||||||
Zfish   639 ELCIPLVVIPATVSNNVPGSDFSVGADTALNTITTTCDRIKQSAAGTKRRVFIIETMGGYCGYLA 703

  Fly   753 TLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSE 817
            |:||||.||||||::|:.|.|.||:.:|.|:..||...|.|||||||||.:.||:|||::.||||
Zfish   704 TMAGLAAGADAAYVFEDPFGIHDLEANVEHLLEKMKTTVKRGLILRNEKCNANYTTDFLFNLYSE 768

  Fly   818 EGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATL 882
            ||||:|.||.|:||||||||:|||||||.||||.||.|.||..::| ....:|.:...:||:|.:
Zfish   769 EGKGVFDCRKNVLGHMQQGGTPTPFDRNFGTKMGAKAVLWLTDKLK-ECYRHGRIFANTPDSACV 832

  Fly   883 LGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKH 927
            ||:..|...|.||.||..:|:|:.||||.:|||:|||:|:||||:
Zfish   833 LGMRKRAMLFQPLSDLKEDTDFEHRIPKTEWWLKLRPILKILAKY 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	429/740 (58%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	439/750 (59%)
pfkmb	NP_001352265.1	Eukaryotic_PFK	136..896	CDD:238389	439/753 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582069
Domainoid	1	1.000	377	1.000	Domainoid score	I817
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20101
Inparanoid	1	1.050	955	1.000	Inparanoid score	I320
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm24665
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	LDO	PTHR13697
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910