Protein Alignment Pfk and Pfkp

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_062677.1
• Gene: Pfkp / 56421
• MGIID: 1891833
• Length: 784
• Species: Mus musculus
• Alignment Length: 754
• Identity: 452/754 - (59%)
• Similarity: 576/754 - (76%)
• Gaps: 10/754 - (1%)

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:.|.|||||:|||||||||.|||.||.|.|||||.|||||:||||..|.||.|..||||:..|
Mouse    24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVG 88

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            |||||||||:.||.|:||||||.||.:.|||||.|||||||||||||||:|||.||:||.:|..|
Mouse    89 GTIIGSARCKAFRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDI 153

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            ..:..:|::.|::||:||||||||||||||||||:|||||||.:|||.:||.||||||::|||||
Mouse   154 DNDTVQKYSYLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGR 218

  Fly   375 HCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPIT 439
            ||||||||..|.|.||::|:||.||:.||.:.:|.:|::.|:..:||||:||:|||:|.:..|||
Mouse   219 HCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKKRLNIIIVSEGAIDMQNKPIT 283

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :|.:|:::.:.|..|.|:|:||||||||.|||||||||.|||.||.:||:|||.::...|:||.|
Mouse   284 SEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACVVSLRG 348

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGI 569
            |||||:||||||:.||.|.|||.|:|:.:|||||||.||.||.|||.|. :|.|.|........:
Mouse   349 NQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLA-IKLPDEKIVKSNCNV 412

  Fly   570 EGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQG 634
                 ||:::||||.||||||||.||..|..|..::.|.||.||...|.::|:||:||.||.|||
Mouse   413 -----AVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQG 472

  Fly   635 GAYLGTKRTLPEGKFKE-IAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPS 698
            |:.|||||||| ||:.| ||.::....|..||||||||:|....::|..|:.:..||:|:|::|:
Mouse   473 GSILGTKRTLP-GKYLEKIAEQMHSHSINALLIIGGFEAYLGLLELAAAREKHEAFCVPMVMVPA 536

  Fly   699 TISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADA 763
            |:||||||::||:|.||.||.||:.||||:|||.|||||||:||||||||||||.:..||.||||
Mouse   537 TVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGALAAGADA 601

  Fly   764 AYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMN 828
            |||:||.|.|.|||.:|.|:..||...:.|||:||||..|.||:|||||:||||||||:|.||.|
Mouse   602 AYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGVFDCRKN 666

  Fly   829 ILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFS 893
            :||||||||:|:|||||.|||::||.::|::|::|.: ...| ....|.|:..:|||..|...|.
Mouse   667 VLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGS-QGTG-KKFVSDDSICVLGICKRDLLFQ 729

  Fly   894 PLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYE 932
            |:.:|...|:|:.||||:||||:|||:::||||::::|:
Mouse   730 PVAELKKVTDFEHRIPKEQWWLKLRPIMKILAKYEASYD 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	451/749 (60%)
Pfkp	NP_062677.1	N-terminal catalytic PFK domain 1	1..398		245/374 (66%)
		Eukaryotic_PFK	21..779	CDD:238389	452/754 (60%)
		Interdomain linker	399..410		3/10 (30%)
		C-terminal regulatory PFK domain 2	411..784		204/366 (56%)