DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfkpa

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_005162582.1	Gene:	pfkpa / 560944	ZFINID:	ZDB-GENE-091112-22	Length:	789	Species:	Danio rerio

Alignment Length:	758	Identity:	456/758 - (60%)
Similarity:	582/758 - (76%)	Gaps:	15/758 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.|||||:|||||||||.|||.||:|.||||:.|||||||||||.|:||.|.:|||::..|
Zfish    18 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFVHEGYQGMVDGGDNIKEATWENVSSMLQVG 82

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            ||:||||||:|||..:||||||:||||||||||.|||||||||||||||:|||.||.|||:...|
Zfish    83 GTVIGSARCKDFRTHEGRLKAAHNLIQRGITNLCVIGGDGSLTGANLFREEWSGLLAELVQQGLI 147

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            ..:..:|::.|||||:||||||||||||||||||:|||||||.:|||.:||.||||||::|||||
Zfish   148 DEDAAQKYSALHIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGR 212

  Fly   375 HCGYLSVVAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPIT 439
            |||||::|:.:...||:|.:||.||:..|.:::..||..:|:..:||||:||||||:||:..|||
Zfish   213 HCGYLALVSALACGADWVLIPEMPPEDGWEEKMCQKLSAKRAGMKRLNIIIVAEGAIDRKNQPIT 277

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :|.||.::..||..|.|:|:||||||||.|||||||||.|||.||.|||:|.|.::...|:||.|
Zfish   278 SEHVKNLVVSRLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLETTANTPACVVSLCG 342

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKP----PKENFDAD 565
            ||:||:||||||:.||.|.|||..||:.:||:|||||||.||:|||:|...||    |..||:
Zfish   343 NQSVRLPLMECVQMTQEVQKAMDGKRFEEAVQLRGRSFENNLKTYKLLAHRKPESELPHSNFN-- 405

  Fly   566 GKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGW 630
                    :||:::||||.||||||||.||..|..|..::.:|||.||...|.::|:.|:||.||
Zfish   406 --------VAVLNVGAPAAGMNAAVRSAVRVGISEGHKMFAVNDGFEGFYKGQIKEIKWADVGGW 462

  Fly   631 VGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVV 695
            .||||:.||||||||.....:||.:::::.|..||:|||||:.....|:.:.|..|.:||||:.:
Zfish   463 TGQGGSLLGTKRTLPAKHIDKIAEQMRKYNINALLVIGGFEALECLLQLNEARAKYEEFCIPLCM 527

  Fly   696 IPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGG 760
            :|:|||||||||:.|:|.||.||.|.|.||||:|||.|||||||:|||||||||||||:.|||.|
Zfish   528 LPATISNNVPGTDLSIGADTALNAIVETCDRIKQSASGTKRRVFIIETMGGYCGYLATVGGLAAG 592

  Fly   761 ADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTC 825
            ||||||:||.|.|:|||.:|.|:..||...:.|||:||||.::|||:|||||:||:|||||:|.|
Zfish   593 ADAAYIFEEPFDIRDLQANVEHLTEKMKTSIQRGLVLRNENSNENYTTDFIYQLYTEEGKGVFDC 657

  Fly   826 RMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDAN-GVVNCKSPDTATLLGIVSRQ 889
            |.|:||||||||:|:|||||.|||::||.:.|:..::..:...: |.|...:.|:|.|||:..|.
Zfish   658 RKNVLGHMQQGGAPSPFDRNFGTKISAKAMQWITKKLNESYRRDEGRVFANTEDSACLLGMRRRA 722

  Fly   890 YRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYE 932
            ..|.|:|.|..||:|..||||:||||:||||::||||:.::|:
Zfish   723 MVFQPVVQLKDETDFVHRIPKEQWWLKLRPLMKILAKYKTSYD 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	444/738 (60%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	455/753 (60%)
pfkpa	XP_005162582.1	Eukaryotic_PFK	15..775	CDD:238389	456/758 (60%)
pfkpa	XP_005162582.1	6PF1K_euk	18..762	CDD:274152	455/753 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582067
Domainoid	1	1.000	443	1.000	Domainoid score	I512
eggNOG	1	0.900	-	-		E1_COG0205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	955	1.000	Inparanoid score	I320
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm24665
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	LDO	PTHR13697
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2168
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800