DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfklb

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001315318.1	Gene:	pfklb / 550259	ZFINID:	ZDB-GENE-050417-62	Length:	779	Species:	Danio rerio

Alignment Length:	766	Identity:	437/766 - (57%)
Similarity:	565/766 - (73%)	Gaps:	16/766 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.|||||:|||||||||..||.|::|.|||.|.|||||:|||||.|:.|||.:|::||..|
Zfish    15 KAIAVLTSGGDAQGMNAAVRAVTRMGIFVGAKVYLIYEGYQGLVDGGDHIKLANWQTVTNIIQLG 79

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            |||||||||:.|...:|||.||.:|:|||||||.|.||||||||||.||.|||.||:|||:...|
Zfish    80 GTIIGSARCKAFTTHEGRLAAAFHLLQRGITNLCVCGGDGSLTGANTFRSEWSGLLEELVQQGRI 144

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |....::...|:||||||||||||||||||||.|:|||||:|.|||||:||.||||||::|||||
Zfish   145 TASLAQQHTHLNIVGLVGSIDNDFCGTDMTIGADSALHRIMEVIDAISTTAQSHQRTFVLEVMGR 209

  Fly   375 HCGYLSVVAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPIT 439
            |||||:||:.:.|.||::|:||:||:..|.|.:..:|.:.||.|.||||||:||||:|::|..|:
Zfish   210 HCGYLAVVSALASGADWLFIPEAPPEDGWEDHMCARLGEVRSKGSRLNIVIIAEGAIDKQGQLIS 274

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :..||.::.:||.:|.|:||||||||||.||||||:|:.:||.||.:||:|||.::...||.|.|
Zfish   275 SSYVKDLVVQRLGYDTRVTVLGHVQRGGTPSAFDRVLSSKMGVEAVVALLEATPETSACVIGLSG 339

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKP--PKENFDADGK 567
            |.|:|:||||||..|:.|.|||.|||:.:|::|||:|||.|..|||:|...||  .|.|
Zfish   340 NHAMRLPLMECVNMTKEVQKAMNEKRFEEAIQLRGKSFENNWNTYKLLAHQKPALSKSN------ 398

  Fly   568 GIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVG 632
                :.:|:::|||||.||||||||.||..:..|..||.::||.|||..|.|.|:.|.||:||.|
Zfish   399 ----HSMAILNIGAPAAGMNAAVRSAVRVGLAHGHRVYTVHDGFEGLAKGMVTEVHWHDVAGWTG 459

  Fly   633 QGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIP 697
            |||:.||||||||....:.|...:.::.||.||:|||||:|....|:.:.|..|.:.||.:.|||
Zfish   460 QGGSLLGTKRTLPNSCMESIVDNISKYDIQSLLVIGGFEAYEGVLQLVEARGRYDELCICMCVIP 524

  Fly   698 STISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGAD 762
            :|||||||||:||||.||.:|...|.||:|:|||.|||||||::|||||:||||||..|:|.|||
Zfish   525 ATISNNVPGTDFSLGADTAVNAAMESCDKIKQSASGTKRRVFIVETMGGFCGYLATTTGIAVGAD 589

  Fly   763 AAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRM 827
            |.|||||.|:|.||:.:|.|:..||...:.|||:|||||..::|:||||:.|||.||:|:|.||:
Zfish   590 AVYIYEEPFNIHDLETNVEHLTDKMKNDIQRGLVLRNEKCHKHYTTDFIHNLYSAEGQGVFDCRV 654

  Fly   828 NILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRF 892
            |:|||:||||.|||||||.|||:..|.|.||...:.|.. ..|.|...:||||.::|:..:...|
Zfish   655 NVLGHLQQGGVPTPFDRNFGTKLGVKAVQWLTEHMSATY-RQGRVFANAPDTACVIGMKKKVMSF 718

  Fly   893 SPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEE 943
            ||:.:|...|:|:.|:||:||||.|||:.::|||:.::::|   |:|.|.|
Zfish   719 SPVTELKEHTDFEHRMPKEQWWLNLRPMQKMLAKYQTSFDE---YVTGEIE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	423/735 (58%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	432/750 (58%)
pfklb	NP_001315318.1	Eukaryotic_PFK	12..772	CDD:238389	437/766 (57%)
pfklb	NP_001315318.1	6PF1K_euk	15..753	CDD:274152	431/748 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582064
Domainoid	1	1.000	443	1.000	Domainoid score	I512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	955	1.000	Inparanoid score	I320
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm24665
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	O	PTHR13697
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910