Protein Alignment Pfk and pfklb

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001315318.1
• Gene: pfklb / 550259
• ZFINID: ZDB-GENE-050417-62
• Length: 779
• Species: Danio rerio
• Alignment Length: 766
• Identity: 440/766 - (57%)
• Similarity: 565/766 - (73%)
• Gaps: 16/766 - (2%)

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.|||||:|||||||||..||.|::|.|||.|.|||||:|||||.|:.|||.:|::||..|
Zfish    15 KAIAVLTSGGDAQGMNAAVRAVTRMGIFVGAKVYLIYEGYQGLVDGGDHIKLANWQTVTNIIQLG 79

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            |||||||||:.|...:|||.||.:|:|||||||.|.||||||||||.||.|||.||:|||:...|
Zfish    80 GTIIGSARCKAFTTHEGRLAAAFHLLQRGITNLCVCGGDGSLTGANTFRSEWSGLLEELVQQGRI 144

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |....::...|:||||||||||||||||||||.|:|||||:|.|||||:||.||||||::|||||
Zfish   145 TASLAQQHTHLNIVGLVGSIDNDFCGTDMTIGADSALHRIMEVIDAISTTAQSHQRTFVLEVMGR 209

  Fly   375 HCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPIT 439
            ||||||:|..||..||::||||.||:..|.|.:|::|.:.||.|.||||||:||||:|::|..|:
Zfish   210 HCGYLAVVSALASGADWLFIPEAPPEDGWEDHMCARLGEVRSKGSRLNIVIIAEGAIDKQGQLIS 274

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :..||.::.:||.:|.|:||||||||||.||||||:|:.:||.||.:||:|||.::...||.|.|
Zfish   275 SSYVKDLVVQRLGYDTRVTVLGHVQRGGTPSAFDRVLSSKMGVEAVVALLEATPETSACVIGLSG 339

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKP--PKENFDADGK 567
            |.|:|:||||||..|:.|.|||.|||:.:|::|||:|||.|..|||:|...||  .|.|
Zfish   340 NHAMRLPLMECVNMTKEVQKAMNEKRFEEAIQLRGKSFENNWNTYKLLAHQKPALSKSN------ 398

  Fly   568 GIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVG 632
                :.:|:::|||||.||||||||.||..:..|..||.::||.|||..|.|.|:.|.||:||.|
Zfish   399 ----HSMAILNIGAPAAGMNAAVRSAVRVGLAHGHRVYTVHDGFEGLAKGMVTEVHWHDVAGWTG 459

  Fly   633 QGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIP 697
            |||:.||||||||....:.|...:.::.||.||:|||||:|....|:.:.|..|.:.||.:.|||
Zfish   460 QGGSLLGTKRTLPNSCMESIVDNISKYDIQSLLVIGGFEAYEGVLQLVEARGRYDELCICMCVIP 524

  Fly   698 STISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGAD 762
            :|||||||||:||||.||.:|...|.||:|:|||.|||||||::|||||:||||||..|:|.|||
Zfish   525 ATISNNVPGTDFSLGADTAVNAAMESCDKIKQSASGTKRRVFIVETMGGFCGYLATTTGIAVGAD 589

  Fly   763 AAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRM 827
            |.|||||.|:|.||:.:|.|:..||...:.|||:|||||..::|:||||:.|||.||:|:|.||:
Zfish   590 AVYIYEEPFNIHDLETNVEHLTDKMKNDIQRGLVLRNEKCHKHYTTDFIHNLYSAEGQGVFDCRV 654

  Fly   828 NILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRF 892
            |:|||:||||.|||||||.|||:..|.|.||...:.|.. ..|.|...:||||.::|:..:...|
Zfish   655 NVLGHLQQGGVPTPFDRNFGTKLGVKAVQWLTEHMSATY-RQGRVFANAPDTACVIGMKKKVMSF 718

  Fly   893 SPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEE 943
            ||:.:|...|:|:.|:||:||||.|||:.::|||:.::::|   |:|.|.|
Zfish   719 SPVTELKEHTDFEHRMPKEQWWLNLRPMQKMLAKYQTSFDE---YVTGEIE 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	435/750 (58%)
pfklb	NP_001315318.1	Eukaryotic_PFK	12..772	CDD:238389	440/766 (57%)