Protein Alignment Pfk and PFKP

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: NP_001397809.1
• Gene: PFKP / 5214
• HGNCID: 8878
• Length: 835
• Species: Homo sapiens
• Alignment Length: 844
• Identity: 469/844 - (55%)
• Similarity: 590/844 - (69%)
• Gaps: 87/844 - (10%)

  Fly   145 APKRKCGKSVDELRKCLRTMQDVIDFVHPVKPFKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLG 209
            |||       ..|||.|..:...           .|.:.|.|||||:|||||||||.|||.||:|
Human     8 APK-------GSLRKFLEHLSGA-----------GKAIGVLTSGGDAQGMNAAVRAVVRMGIYVG 54

  Fly   210 CKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGI 274
            .|||||.||||||||||..|.||:|.|||||:..|||||||||||.||.|:||||||.||:||||
Human    55 AKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGI 119

  Fly   275 TNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMT 339
            |||.|||||||||||||||:|||.||:||.:|..|..|..:|:..|::||:||||||||||||||
Human   120 TNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184

  Fly   340 IGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWP 404
            ||||:|||||||.:|||.:||.||||||::|||||||||||||..|||.||::|:||.||:..|.
Human   185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWE 249

  Fly   405 DRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNP 469
            :::|.:|::.|:..:||||:||||||:|.:..|||:|.:|:::..:|.:|.|:|:||||||||.|
Human   250 EQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTP 314

  Fly   470 SAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADA 534
            ||||||||.|||.||.:||:|||.|:...|:||:||.|||:||||||:.||.|.|||.|:|:.||
Human   315 SAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDA 379

  Fly   535 VKLRGRSFERNLETYKMLTRLKP----PKENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVR 595
            |:||||||..||.|||.|....|    ||.|.:          :||:::||||.||||||||.||
Human   380 VRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCN----------VAVINVGAPAAGMNAAVRSAVR 434

  Fly   596 NAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFK 660
            ..|..|..:..|.||.:|...|.::|:||:||.||.||||:.|||||.||....:|||.:::...
Human   435 VGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHS 499

  Fly   661 IQGLLIIGGFE---------------------------------------------------SYH 674
            |..||||||||                                                   :|.
Human   500 INALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDAYK 564

  Fly   675 AAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVF 739
            :|..:|:.|..:.:.|||:.|:|:||||||||||.|||.|||||.:.|.||||:|||.|||||||
Human   565 SACDMAEARGRHQELCIPLCVVPATISNNVPGTEISLGSDTGLNAVVETCDRIKQSASGTKRRVF 629

  Fly   740 VIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASE 804
            :||||||||||||.:.|||.|||||||:||.|.|:|||.:|.|:..||...:.|||:||||..||
Human   630 IIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSE 694

  Fly   805 NYSTDFIYRLYSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDAN 869
            ||:|||||:||||||||:|.||.|:||||||||:|:|||||.|||::|:.::|:.|::|   :|.
Human   695 NYTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLK---EAR 756

  Fly   870 G-VVNCKSPDTATLLGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYE 932
            | .....:.|:..:|||..|...|.|:.:|..:|:|:.||||:||||:||||::||||:.::|:
Human   757 GRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYD 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	461/804 (57%)
PFKP	NP_001397809.1	Eukaryotic_PFK	22..834	CDD:238389	462/823 (56%)