DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and PFKM

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_001341664.1	Gene:	PFKM / 5213	HGNCID:	8877	Length:	883	Species:	Homo sapiens

Alignment Length:	796	Identity:	461/796 - (57%)
Similarity:	599/796 - (75%)	Gaps:	22/796 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 KKKKSAPKRKCGKSVDELRKCLRTMQDVIDFV------HPVKPFK-DKGLAVFTSGGDSQGMNAA 197
            |:|::..|.:...:|:       ||:...:::      |..|... .|.:||.|||||:||||||
Human    79 KRKRAVVKARGDPTVE-------TMKQREEWIMTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAA 136

  Fly   198 VRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGR 262
            |||.||:.|:.|.:|:|:.|||||:|||||.|:||.|.|||.::..|||:||||||:|||||:||
Human   137 VRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGR 201

  Fly   263 LKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVG 327
            |:||.||::||||||.|||||||||||:.||.|||.||.:|.|...||.|:..|.:.|:||||||
Human   202 LRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVG 266

  Fly   328 SIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLSVVAGIISEADYV 392
            ||||||||||||||||:|||||:|.:|||::||.||||||::||||||||||::|..:...||:|
Human   267 SIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWV 331

  Fly   393 FLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARI 457
            |:||.||..||.:.|..:|.:.|:.|.||||:||||||:|:.|.|||:||:|.::.:||.:|.|:
Human   332 FIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRV 396

  Fly   458 TVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAV 522
            ||||||||||.||||||||..|||.||.:||:|.|.|:...|:||.||||||:||||||:.|:.|
Human   397 TVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDV 461

  Fly   523 AKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIEGYRLAVMHIGAPACGMN 587
            .|||.||::.:|:|||||||..|.|.||:|..::||.....:       :.:|||::||||.|||
Human   462 TKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGS-------HTVAVMNVGAPAAGMN 519

  Fly   588 AAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEI 652
            |||||.||..:.:|:.|..::||.|||..|.:.|.|||.|.||.||||:.||||||||:..|::|
Human   520 AAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQI 584

  Fly   653 AARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGL 717
            :|.:.:|.||||:||||||:|....::.:.|..:.:.|||.||||:|:||||||::||:|.||.|
Human   585 SANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTAL 649

  Fly   718 NEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYH 782
            |.|...||||:|||.|||||||:|||||||||||||:||||.|||||||:||.|:|:|||.:|.|
Human   650 NTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEH 714

  Fly   783 MASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMG 847
            :..||...|.|||:|||||.:|||:||||:.||||||||:|..|.|:||||||||||||||||..
Human   715 LVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFA 779

  Fly   848 TKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDLIAETNFDQRIPKKQ 912
            |||.||.::|::.:||.:. .||.:...:||:..:||:..|...|.|:.:|..:|:|:.||||:|
Human   780 TKMGAKAMNWMSGKIKESY-RNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQ 843

  Fly   913 WWLRLRPLLRILAKHD 928
            |||:|||:|:||||::
Human   844 WWLKLRPILKILAKYE 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	442/736 (60%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	453/749 (60%)
PFKM	NP_001341664.1	Eukaryotic_PFK	116..877	CDD:238389	453/752 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148146
Domainoid	1	1.000	433	1.000	Domainoid score	I585
eggNOG	1	0.900	-	-		E1_COG0205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20101
Inparanoid	1	1.050	950	1.000	Inparanoid score	I340
Isobase	1	0.950	-	0	Normalized mean entropy	S685
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm40571
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	LDO	PTHR13697
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2168
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750