Protein Alignment Pfk and PFKL

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_006724074.1
• Gene: PFKL / 5211
• HGNCID: 8876
• Length: 853
• Species: Homo sapiens
• Alignment Length: 768
• Identity: 425/768 - (55%)
• Similarity: 557/768 - (72%)
• Gaps: 37/768 - (4%)

  Fly   188 GGDS-----QGMNAAVRACVRMAIYLGCKVYFIRE-----------------------GYQGMVD 224
            ||.|     .||||||||..||.||:|.||:.|.|                       ||:|:|:
Human    69 GGTSIMSRLGGMNAAVRAVTRMGIYVGAKVFLIYEEQRMPYCLSPSPRGRFGARPPSWGYEGLVE 133

  Fly   225 GGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGA 289
            ||:.|::|||.|||:||..||||||||||:.|..|:||..||.||:|.|||||.|||||||||||
Human   134 GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGA 198

  Fly   290 NLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAID 354
            |:||.||.|||:|||....|:......::.|:|.||||||||||||||||||||:|||||:|.||
Human   199 NIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVID 263

  Fly   355 AISSTAYSHQRTFIMEVMGRHCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQ 419
            ||::||.||||||::|||||||||||||..||..||::||||.||:..|.:.:|.:|.:.||.|.
Human   264 AITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGS 328

  Fly   420 RLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEA 484
            ||||:|:||||:||.|.||::..||.::.:||..|.|:||||||||||.||||||||:.:||.||
Human   329 RLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEA 393

  Fly   485 TLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETY 549
            .:||:|||.|:...|::|.|||:||:||||||:.|:.|.|||.:||:.:|.:|||.|||.|...|
Human   394 VMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIY 458

  Fly   550 KMLTRLKPPKENFDADGKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGL 614
            |:|...|||||.        ..:.||::::||||.||||||||.||..|..|..||.::||.|||
Human   459 KLLAHQKPPKEK--------SNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGL 515

  Fly   615 IAGNVRELGWSDVSGWVGQGGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQI 679
            ..|.|:|:||.||:||:|:||:.||||||||:|:.:.|...::.:.|..||::||||:|....|:
Human   516 AKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQL 580

  Fly   680 ADQRDNYPQFCIPIVVIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETM 744
            .:.|..|.:.||.:.|||:|||||||||:||||.||.:|...|.||||:|||.|||||||::|||
Human   581 VEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETM 645

  Fly   745 GGYCGYLATLAGLAGGADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTD 809
            |||||||||:.|:|.||||||::|:.|:|.||:.:|.||..||...:.|||:|||||..:.|:|:
Human   646 GGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTE 710

  Fly   810 FIYRLYSEEGKGLFTCRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNC 874
            |:|.|||.||||:|.||.|:|||:||||:|||||||.|||:..|.:.||:.::: .:...|.|..
Human   711 FLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLR-EVYRKGRVFA 774

  Fly   875 KSPDTATLLGIVSRQYRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKH 927
            .:||:|.::|:..:...|||:.:|..:|:|:.|:|::||||.||.:|::||::
Human   775 NAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	425/768 (55%)
PFKL	XP_006724074.1	Eukaryotic_PFK	79..846	CDD:238389	422/758 (56%)