DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and Pfkl

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	XP_038954392.1	Gene:	Pfkl / 25741	RGDID:	3311	Length:	838	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	430/822 - (52%)
Similarity:	571/822 - (69%)	Gaps:	70/822 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIRE--------------------------- 217
            |.:.|.|||||:|||||||||..||.||:|.||:.|.|
  Rat    16 KAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYESLEDQPGQEDQQGGTNRRHPTYAVLAQ 80

  Fly   218 -------------------------------GYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSA 251
                                           ||:|:|:||:.|:.|||.|||:||..||||||||
  Rat    81 FHLPPHPQAYVQAERHIRKQNGDPGAPAGTVGYEGLVEGGENIKPANWLSVSNIIQLGGTIIGSA 145

  Fly   252 RCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEK 316
            ||:.|..|:|||.||.||:|.|||||.||||||||||||:||.||.|||:||||...|:....:.
  Rat   146 RCKAFTTREGRLAAAYNLLQHGITNLCVIGGDGSLTGANIFRNEWGSLLEELVKEGKISESTAQN 210

  Fly   317 FNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLSV 381
            :..|.|.||||||||||||||||||||:|||||:|.||||::||.||||||::||||||||||::
  Rat   211 YAHLSIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLAL 275

  Fly   382 VAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKV 446
            |:.:.|.||::|:||:||:..|.:.:..:|.:.||.|.||||:|:||||:||.|.||::..||.:
  Rat   276 VSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRHGKPISSSYVKDL 340

  Fly   447 IDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVP 511
            :.:||..|.|:||||||||||.||||||:|:.:||.||.:||:|||.|:...|:||.|||:||:|
  Rat   341 VVQRLGFDTRVTVLGHVQRGGTPSAFDRVLSSKMGMEAVMALLEATPDTPACVVSLSGNQSVRLP 405

  Fly   512 LMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGIEGYRLAV 576
            |||||:.|:.|.|||.|||:.:|::|||||||.|.:.||:|...|..||.        ..:.||:
  Rat   406 LMECVQVTKDVQKAMDEKRFDEAIQLRGRSFENNWKIYKLLAHQKVSKEK--------SNFSLAI 462

  Fly   577 MHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQGGAYLGTK 641
            :::||||.||||||||.||..|..|..||.::||.|||..|.|:|:||.||:||:|:||:.||||
  Rat   463 LNVGAPAAGMNAAVRSAVRTGISEGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTK 527

  Fly   642 RTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPG 706
            ||||:...:.|...|:.:.|..||:|||||:|....|:.:.|..|.:.||.:.|||:||||||||
  Rat   528 RTLPKPHLEAIVENLRTYNIHALLVIGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPG 592

  Fly   707 TEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKF 771
            |:||||.||.:|...|.||||:|||.|||||||::||||||||||||:.|:|.||||||::|:.|
  Rat   593 TDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPF 657

  Fly   772 SIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNILGHMQQG 836
            :|.||:.:|.||..||...:.|||:|||||..|:|:|:|:|.|||.||:|:|.||.|:|||:|||
  Rat   658 NIHDLKANVEHMTEKMKTDIQRGLVLRNEKCHEHYTTEFLYNLYSSEGRGVFDCRTNVLGHLQQG 722

  Fly   837 GSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDLIAE 901
            |:|||||||.|||:..|.:.|::.::: ::...|.|...:||:|.::|:..:...||.:.:|..|
  Rat   723 GAPTPFDRNYGTKLGVKAMLWMSEKLR-DVYRKGRVFANAPDSACVIGLRKKVVAFSSVTELKKE 786

  Fly   902 TNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEE 943
            |:|:.|:|::||||.||.:|::||.:..:..:   |::.|.|
  Rat   787 TDFEHRMPREQWWLNLRLMLKMLAHYRISMAD---YVSGELE 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	419/791 (53%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	427/806 (53%)
Pfkl	XP_038954392.1	Eukaryotic_PFK	13..831	CDD:238389	430/822 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342018
Domainoid	1	1.000	430	1.000	Domainoid score	I572
eggNOG	1	0.900	-	-		E1_COG0205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	940	1.000	Inparanoid score	I328
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		otm44709
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	O	PTHR13697
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770